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We analysed masses of individual phospholipid (PL) classes and neutral lipid mass as well as PL acyl chain composition in brains from wild\u2010type and <jats:italic>Snca<\/jats:italic><jats:sup><jats:italic>\u2010\/\u2010<\/jats:italic><\/jats:sup> mice. Although total brain PL mass was not altered, cardiolipin and phosphatidylglycerol mass decreased 16% and 27%, respectively, in <jats:italic>Snca<\/jats:italic><jats:sup><jats:italic>\u2010\/\u2010<\/jats:italic><\/jats:sup> mice. In addition, no changes were observed in plasmalogen or polyphosphoinositide mass. In ethanolamine glycerophospholipids and phosphatidylserine, docosahexaenoic acid (22\u2003:\u20036n\u20103) was decreased 7%, while 16\u2003:\u20030 was increased 1.1\u2010fold and 1.4\u2010fold, respectively. Surprisingly, brain cholesterol, cholesteryl ester, and triacylglycerol mass were increased 1.1\u2010fold, 1.6\u2010fold, and 1.4\u2010fold, respectively in <jats:italic>Snca<\/jats:italic><jats:sup><jats:italic>\u2010\/\u2010<\/jats:italic><\/jats:sup> mice. In isolated myelin, cholesterol mass was also increased 1.3\u2010fold, but because there was also a net increase in myelin PL mass, the cholesterol to PL ratio was unaltered. No changes in the expression of cholesterogenic enzymes were observed, suggesting these did not account for the observed changes in cholesterol. These data extend our previous results in astrocytes and kinetic studies <jats:italic>in vivo<\/jats:italic> demonstrating a role for Snca in brain lipid metabolism and demonstrate a clear impact on brain neutral lipid metabolism.<\/jats:p>","DOI":"10.1111\/j.1471-4159.2006.04348.x","type":"journal-article","created":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T11:43:55Z","timestamp":1169552635000},"page":"132-141","source":"Crossref","is-referenced-by-count":96,"title":["Brain neutral lipids mass is increased in \u03b1\u2010synuclein gene\u2010ablated mice"],"prefix":"10.1111","volume":"101","author":[{"given":"Gwendolyn","family":"Barcel\u00f3\u2010Coblijn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail Y.","family":"Golovko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Weinhofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500634102"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535805"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(75)35171-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1016\/S0021-9258(19)42106-6","article-title":"Suppression of 3\u2010hydroxy\u20103\u2010methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7\u2010ketocholesterol","volume":"249","author":"Brown M. 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