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The finding that the neuromuscular\u2010blocking activity of mecamylamine at<jats:italic>p<\/jats:italic>H 6.7 was similar to the activity at<jats:italic>p<\/jats:italic>H 7.7 did not refute this conclusion. Mecamylamine, dimecamine methiodide, dimecamine and pempidine, at concentrations insufficient to cause block, could increase the twitch response of the rat diaphragm; the ability to do this increased in the above order. With pempidine (the most active compound) this effect, on the isolated sartorius muscle of the frog, was a direct action. During steady partial block by each of the compounds, the responses to brief tetanic stimulation, to neostigmine and to an increase in calcium concentration were similar to those observed during block by tubocurarine. From indirect evidence, pempidine methiodide appeared both to enhance the release of acetylcholine from motor\u2010nerve terminals and to cause postsynaptic block.<\/jats:p>","DOI":"10.1111\/j.1476-5381.1964.tb01543.x","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T18:12:50Z","timestamp":1342807970000},"page":"56-65","source":"Crossref","is-referenced-by-count":5,"title":["ACTIONS OF MECAMYLAMINE, DIMECAMINE, PEMPIDINE AND THEIR TWO QUATERNARY METHO\u2010SALTS AT THE NEUROMUSCULAR JUNCTION"],"prefix":"10.1111","volume":"22","author":[{"given":"J. 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