{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T15:43:12Z","timestamp":1776958992759,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":14536,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1972,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:list list-type=\"explicit-label\"><jats:list-item><jats:p>. Effects of morphine sulphate (1\u00b725, 2\u00b75, 5, 10, 20 and 40 mg\/kg i.p.) on locomotor activity of male rats were observed for 8 h after single doses in non\u2010tolerant rats. The lower three doses had only an excitatory effect, whereas the higher three doses caused initial depression followed by a delayed excitatory effect.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>. The same doses of morphine were administered daily for 30 days. No tolerance developed within this time to the excitatory effect. The locomotor excitatory effect of the higher three doses of morphine became progressively more pronounced over treatment periods of 30 days (and 48 days for 20 mg\/kg), while the latency to peak activity decreased.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>. An explanation of these results is suggested on the basis of two different central drug\u2010receptor interactions affecting motility.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1111\/j.1476-5381.1972.tb06866.x","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T13:21:18Z","timestamp":1342790478000},"page":"213-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":370,"title":["Time\u2010dose relationships for locomotor activity effects of morphine after acute or repeated treatment"],"prefix":"10.1111","volume":"46","author":[{"given":"M.","family":"BABBINI","sequence":"first","affiliation":[]},{"given":"W. M.","family":"DAVIS","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2012,7,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"237","article-title":"Effect of morphine on the exploratory drive","volume":"11","author":"Beach H. D.","year":"1957","journal-title":"Can. J. Physiol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1965.16.3.693"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/2251152a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00404736"},{"key":"e_1_2_1_6_1","volume-title":"McGraw\u2010Hill Series in Probability and Statistics","author":"Graybill F. A.","year":"1961"},{"issue":"204","key":"e_1_2_1_7_1","first-page":"1","article-title":"Catecholamines and 5\u2010hydroxytryptamine in morphine tolerance and withdrawal","volume":"58","author":"Gunne L. M.","year":"1963","journal-title":"Acta physiol. scand."},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0022-3565(25)28909-1","article-title":"Morphine\u2010induced hyperalgesia in rats tested on the hot plate","volume":"177","author":"Kayan S.","year":"1971","journal-title":"J. Pharmac. exp. Ther."},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0022-3565(25)11647-9","article-title":"Nalorphine\u2010induced \u2018abstinence syndrome\u2019 in morphine\u2010tolerant albino rats","volume":"117","author":"Kaymakcalan S.","year":"1956","journal-title":"J. Pharmac. exp. Ther."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1971.tb07132.x"},{"key":"e_1_2_1_11_1","first-page":"275","volume-title":"Physiological Pharmacology","author":"Martin W. R.","year":"1963"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00408180"},{"key":"e_1_2_1_13_1","first-page":"189","article-title":"Dose\u2010related aspects of tolerance to the analgesic effect of chronically administered morphine sulfate (MS) in mice","volume":"10","author":"Miller J. M.","year":"1968","journal-title":"Pharmacologist"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/1420381"},{"key":"e_1_2_1_15_1","first-page":"514","article-title":"A critique of the \u2018dual action\u2019 hypothesis of morphine\u2010physical dependence","volume":"140","author":"Seevers M. G.","year":"1962","journal-title":"Archs int. Pharmacodyn."},{"key":"e_1_2_1_16_1","first-page":"565","volume-title":"Physiological Pharmacology","author":"Seevers M. G.","year":"1963"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(53)90370-2"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0022-3565(25)26531-4","article-title":"A simple method for producing tolerance to dihydromorphinone in mice","volume":"140","author":"Shuster L.","year":"1963","journal-title":"J. Pharmac., exp. Ther"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00411369"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0022-3565(25)04096-0","article-title":"Morphine addiction and its physiological interpretation based on experimental evidence","volume":"36","author":"Tatum A. L.","year":"1929","journal-title":"J. Pharmac. exp. Ther."},{"key":"e_1_2_1_21_1","first-page":"425","article-title":"Richerche actografiche ed elettroforetiche sul morfinismo nel ratto","volume":"9","author":"Tonini G.","year":"1959","journal-title":"Archo ital. Sci. farmac."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177731677"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0022-3565(25)11264-0","article-title":"Locus of emetic action of morphine and hydergine in dogs","volume":"111","author":"Wang S. C.","year":"1954","journal-title":"J. Pharmac. exp. Ther."}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1476-5381.1972.tb06866.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1476-5381.1972.tb06866.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:23:36Z","timestamp":1743812616000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5381.1972.tb06866.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,10]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,10]]}},"alternative-id":["10.1111\/j.1476-5381.1972.tb06866.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1476-5381.1972.tb06866.x","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,10]]},"assertion":[{"value":"2012-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}