{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:41:16Z","timestamp":1757702476698},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":12893,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1977,4]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>In order to discover whether the changes in reactivity are related to the primary cause of hypertension in spontaneously hypertensive rats (SHR) or are just an adaptation induced by the high arterial blood pressure we tested the contractile response of a visceral smooth muscle from such rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Longitudinal strips of the fundus from 20 week old male and female SHR and Wistar normotensive (NW) rats were used. Dose\u2010response curves to Ba<jats:sup>2+<\/jats:sup> in SHR strips were displaced to the right as compared to NW rats. Maximal responses were identical. Male SHR fundus strips contracted much more with Sr<jats:sup>2+<\/jats:sup> (SHR: 42 \u00b1 3% of maximum response to Ba<jats:sup>2+<\/jats:sup>, <jats:italic>n<\/jats:italic>= 10; NW: 19 \u00b1 4%, <jats:italic>n=<\/jats:italic> 10, <jats:italic>P<\/jats:italic>&lt;0.01) than NW strips. There was no difference in the response to both BaCl<jats:sub>2<\/jats:sub> and SrCl<jats:sub>2<\/jats:sub> between female SHR and NW fundus strips, and MnCl<jats:sub>2<\/jats:sub> and LaCl<jats:sub>3<\/jats:sub> were relaxant in all cases.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Dose\u2010response curves to Ca<jats:sup>2+<\/jats:sup> of depolarized SHR and NW fundus strips were obtained and the effect of diazoxide on Ca<jats:sup>2+<\/jats:sup> contractions was observed. The contractile action of Ca<jats:sup>2+<\/jats:sup> in depolarized preparations was enhanced in both male and female SHR strips. The effect of diazoxide was more marked in SHR strips than in NW fundus strips.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SHR fundus smooth muscle shows the same modification of reactivity to Ba<jats:sup>2+<\/jats:sup>, Sr<jats:sup>2+<\/jats:sup>, Ca<jats:sup>2+<\/jats:sup> and diazoxide that was previously described in arterial smooth muscle. This indicates that the cellular modification responsible for the increase of vascular tonus in SHR is not an adaptive reaction to high blood pressure. The differences between female SHR and male SHR responses are not unexpected, considering the natural evolution of hypertension in Okamoto rats which is milder in the female.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1111\/j.1476-5381.1977.tb07730.x","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T14:58:02Z","timestamp":1342796282000},"page":"621-625","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["EVIDENCE FOR A VISCERAL SMOOTH MUSCLE ABNORMALITY IN OKAMOTO SPONTANEOUS HYPERTENSION"],"prefix":"10.1111","volume":"59","author":[{"given":"J.","family":"ALTMAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"DA PONTE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"WORCEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"127","article-title":"Reactivity of vascular smooth muscle from normal and hypertensive rats: effects of several cations","volume":"33","author":"Bohr D.F.","year":"1974","journal-title":"Fed Proc."},{"key":"e_1_2_1_3_1","first-page":"235","volume-title":"Smooth Muscle Pharmacology & Physiology","author":"Brading A.F.","year":"1976"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.31.3.356"},{"key":"e_1_2_1_5_1","first-page":"103","volume-title":"Igaku Shoin Tokyo","author":"Folkow B.","year":"1972"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.34.030172.000305"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(76)90183-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.36.6.208"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-65441-1_22"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-65343-8_51"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1152\/ajplegacy.1969.217.5.1310","article-title":"Characteristics of 45Ca binding in vascular smooth muscle","volume":"217","author":"Hudgins P.M.","year":"1969","journal-title":"Am. 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