{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:59:57Z","timestamp":1770335997261,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":11767,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1980,5]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p><jats:italic>N,N<\/jats:italic>\u2010Dimethyltryptamine (DMT) in pargyline pretreated rodents induced a dose\u2010dependent behavioural syndrome consisting of hyperactivity, prostration and hindlimb abduction, mild tremor, Straub tail, retropulsion and jerking.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In rats pretreated with pargyline, the behavioural syndrome induced by DMT differed from that induced by <jats:sc>l<\/jats:sc>\u2010tryptophan or quipazine, in the lack of forepaw treading and head\u2010weaving and in the presence of only mild tremor.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The hyperactivity component of the DMT\u2010induced behavioural syndrome in pargyline\u2010pretreated mice was potentiated by cyproheptadine, methergoline, and mianserin, inhibited by cinanserin, haloperidol, pimozide, methiothepin and propranolol, and not affected by 501C67\u2010sulphate and methysergide.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The maximal behavioural changes induced by DMT in rats, other than hyperactivity, were unaffected by pretreatment with cyproheptadine, methysergide, and cinanserin. However, propranolol reduced the intensity of all behavioural effects apart from body jerking, and methergoline decreased the duration of prostration. Phenoxybenzamine and haloperidol, in contrast, enhanced prostration.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>DMT plus pargyline did not induce circling behaviour in mice with a unilateral 6\u2010hydroxydopamine lesion of the nigro\u2010striatal pathway.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The DMT\u2010induced behavioural syndrome appears to consist of two components, (a) hyperactivity and (b) other behavioural changes. They differ in their response to drugs affecting brain monoamines. The hyperactivity component may be expressed via dopamine mechanisms, but the other behavioural changes are not. 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