{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:16:44Z","timestamp":1770153404543,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":8753,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Mechanisms involved in neutrophil accumulation induced by intradermal injection of interleukin\u20101 (IL\u20101) in the rabbit were investigated using intravenously\u2010injected <jats:sup>111<\/jats:sup>In\u2010labelled neutrophils. C5a des Arg, N\u2010formyl\u2010methionyl\u2010leucyl\u2010phenylalanine (FMLP) and leukotriene B<jats:sub>4<\/jats:sub> (LTB<jats:sub>4<\/jats:sub>) were included for comparison.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Local inhibition of protein biosynthesis in the skin using actinomycin\u2010D or cycloheximide blocked <jats:sup>111<\/jats:sup>In\u2010neutrophil accumulation induced by IL\u20101, but not that induced by the other mediators.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Actinomycin\u2010D and cycloheximide had no effect on local plasma protein leakage induced by intradermally\u2010injected C5a des Arg, or that induced by zymosan. <jats:sup>111<\/jats:sup>In\u2010neutrophil accumulation induced by zymosan was, however, partially suppressed.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A monoclonal antibody, MoAb 60.3, recognising neutrophil surface CD18 antigen, was preincubated with <jats:sup>111<\/jats:sup>In\u2010neutrophils before intravenous injection. This pretreatment did not affect circulating numbers of radiolabelled cells, but it inhibited their accumulation in response to IL\u20101, C5a des Arg and the other mediators.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results suggest that neutrophil accumulation induced by IL\u20101, but not the other mediators, requires local protein biosynthesis, probably in the microvascular endothelium. Neutrophil accumulation to IL\u20101 and the other mediators appears to require neutrophil surface antigen, CD18. 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