{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:58:42Z","timestamp":1774439922169,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":8692,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The relaxation responses of pre\u2010constricted pig coronary artery (PCA) and rabbit aorta (RA) without endothelium, to endothelium\u2010derived relaxing factor (EDRF) released from either a PCA or RA with intact endothelium have been studied by use of a bioassay cascade system. Effects of EDRF have been compared with sodium nitroprusside (NaNP) and 8\u2010bromo\u2010cyclic GMP.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The time course of changes in cyclic GMP levels in response to EDRF in PCA and RA have also been studied.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>EDRF (released from a PCA or RA) caused significantly greater relaxation in the PCA than the RA, whether 5\u2010hydroxytryptamine or high extracellular potassium was used as the constrictor agonist.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These differences in sensitivity to EDRF were paralleled by NaNP but not 8\u2010bromo\u2010cyclic GMP.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cyclic GMP levels peaked earlier in the RA (30 s) than in the PCA (180 s) but the peak levels were significantly greater in the PCA (2.45 fold) than the RA (1.48 fold).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data show that the previously described differences in EDRF activity between different artery types can be explained in part by differences in the responsiveness of the smooth muscle to EDRF.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1111\/j.1476-5381.1988.tb11685.x","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T20:41:57Z","timestamp":1342816917000},"page":"630-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Vascular smooth muscle sensitivity to endothelium\u2010derived relaxing factor is different in different arteries"],"prefix":"10.1111","volume":"95","author":[{"given":"M.I.","family":"Christie","sequence":"first","affiliation":[]},{"given":"M.J.","family":"Lewis","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2012,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1986.tb16249.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01907912"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198611000-00010"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017127"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015228"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/308645a0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90496-0"},{"key":"e_1_2_1_10_1","first-page":"23","article-title":"Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine","volume":"3","author":"KATSUKI S.","year":"1977","journal-title":"J. Cyclic Nucleotide Res"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582596"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.52.3.352"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1476-5381.1988.tb11685.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1476-5381.1988.tb11685.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T12:01:45Z","timestamp":1697889705000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5381.1988.tb11685.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1111\/j.1476-5381.1988.tb11685.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1476-5381.1988.tb11685.x","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]},"assertion":[{"value":"2012-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}