{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:12:39Z","timestamp":1698052359755},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":8115,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effects of calcitonin gene\u2010related peptide (CGRP) on mechanical and electrophysiological responses were studied in the guinea\u2010pig atrial muscle preparations and in single cells.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CGRP (&gt;10<jats:sup>\u22129<\/jats:sup><jats:sc>m<\/jats:sc>) enhanced the twitch contraction in a concentration\u2010dependent manner in electrically driven left atria and increased heart rate in spontaneously beating right atria. The positive inotropic and chronotropic effects of CGRP were not inhibited by propranolol but were attenuated by reduction of the calcium concentration in the bathing medium.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In single left atrial cells, CGRP slightly hyperpolarized the resting potential but did not affect the other action potential parameters significantly.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Under whole\u2010cell voltage\u2010clamp conditions, CGRP increased the calcium inward current. The peptide also increased the steady inward current elicited by hyperpolarization and the late outward current by depolarization.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest that CGRP may produce the positive inotropic and presumably chronotropic effects by increasing calcium inward current. CGRP also increases the potassium permeability. Such effects on ionic currents may not produce any apparent change in the action potential conformation, due to their opposite directional actions and relatively weak potencies.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1111\/j.1476-5381.1990.tb12046.x","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T14:27:59Z","timestamp":1342794479000},"page":"27-30","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Electrophysiological and mechanical effects of calcitonin gene\u2010related peptide on guinea\u2010pig atria"],"prefix":"10.1111","volume":"100","author":[{"given":"Tsuyoshi","family":"Ohmura","sequence":"first","affiliation":[]},{"given":"Matomo","family":"Nishio","sequence":"additional","affiliation":[]},{"given":"Shigeru","family":"Kigoshi","sequence":"additional","affiliation":[]},{"given":"Ikunobu","family":"Muramatsu","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2012,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/298240a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011853"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/295345a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00634231"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90019-1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554909"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.63.4.726"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014054"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/308653a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90661-8"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.43.113"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90156-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169537"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb12973.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010716"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/304129a0"},{"key":"e_1_2_1_18_1","first-page":"731","article-title":"Role of calcitonin gene\u2010related peptide (CGRP) as cardiotonic neurotransmitter in guinea\u2010pig left atria","volume":"243","author":"SAITO A.","year":"1987","journal-title":"J. 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