{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:16:54Z","timestamp":1769606214705,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,11,5]],"date-time":"2007-11-05T00:00:00Z","timestamp":1194220800000},"content-version":"vor","delay-in-days":11845,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[1975,6]]},"abstract":"<jats:sec><jats:title>SUMMARY<\/jats:title><jats:p>Nineteen probands with benign epilepsy of childhood and centrotemporal EEG foci (rolan\u2010dic discharges), 36 of their full parents, and 34 full siblings were included in a genetic study. In these sibships (excluding probands), 15% (5\/34) had seizures and rolandic discharges, and 19% (6\/32) had rolandic discharges alone. Of the full parents, 11% (5\/38) had seizures in childhood but none in adult life. Only 1 parent (3%) of 36 had rolandic discharges. There was no difference with sex. The results were tested against different genetic hypotheses and indicate that an autosomal dominant gene with age\u2010dependent penetrance is responsible for the EEG trait.<\/jats:p><\/jats:sec><jats:sec><jats:title>R\u00c9SUM\u00c9<\/jats:title><jats:p>Dans une \u00e9tude g\u00e9n\u00e9tique on a pris en consid\u00e9ration 19 propositus avec \u00e9pilepsie b\u00e9nigne de l'enfance s'accompagnant de foyers dans la r\u00e9gion centro\u2010temporale (d\u00e9charges rolandiques), 36 parents et 34 fr\u00e8res et soeurs. Dans ces fatries (sans propositus), 15% (5\/34) pr\u00e9sentaient des crises et des d\u00e9charges rolandiques et 19% (6\/32) seulement des d\u00e9charges rolandiques. Parmi les parents 11% (5\/36) avaient des crises dans l'enfance qui ne se repr\u00e9sentaient plus dans l'\u00e2ge adulte. Il n'y avait pas des diff\u00e9rences de sexe. Ces r\u00e9sultats testes su\u00edvant diff\u00e9rentes hypoth\u00e8ses g\u00e9n\u00e9tiques, indiquent qu'un g\u00e8ne autosomique dominant dont la p\u00e9n\u00e9trance depend de l'\u00e2ge est responsable des caract\u00e9ristiques EEG.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESUMEN<\/jats:title><jats:p>Se ha realizado un estud<jats:sub>10<\/jats:sub> gen\u00e9tico incluyendo 19 probandos con epilepsy\u00eda benigna y focos electroencefalogr\u00e1ficos centrotemporales (descargas rol\u00e1ndicas), 36 de sus progenitores y 34 hermanos completes. En el grupo de hermanos (excluyendo los probandos) un 15% (5 de 34) ten\u00edan ataques y descargas rol\u00e1ndicas y un 19% (6 de 32) ten\u00edan solo descargas rol\u00e9ndicas. Once por ciento de los progenitores verdaderos (5 de 38) tuvieron ataques durante la infancia pero no en la edad adulta. Solamente un progenitor de 36 (3%) tuvo descargas rolandicas. No se hallaron diferencias relacion\u2010ables al sexo. Se compararon los resultados con diferentes hip\u00f3tesis gen\u00e9ticas y se sac\u00f3 como conclusi\u00f3n que existe un gene antos\u00f3mico dominante, con penetrancia dependiente de la edad, responsable del estigma electroencefalo\u2010gr\u00e1fico.<\/jats:p><\/jats:sec><jats:sec><jats:title>ZUSAMMENFASSUNG<\/jats:title><jats:p>In die genetische Studie wurden aufgenom\u2010men: 19 Patienten mit kindlicher benigner Epilepsie und zentro\u2010temporalen EEG\u2010Foci (Rolandischen Spikes), ihre Eltern (36 Pro\u2010banden) und Geschwister (34 Probanden). Von dieseh Geschwistem (ohne Patienten) hatten 15% (5\/34) Anf\u00e4lle und Rolandische Spikes, 19% (6\/32) ledighch Rolandische Spikes. 11% (5\/38) aller Elternteile hatten Anf\u00e4lle in der Kindheit, jedoch nicht im Erwachsenenalter. Nur ein Elternteil (3%) von 36 bot Rolandische Spikes. Geschlechtsunterschiede fanden sich nicht. Die Ergebnisse wurden gegen verschied\u2010ene genetische Hypothesen getestet. Sie sprechen daf\u00fcr, dass ein autosomal\u2010domi\u2010nantes Gen mit altersabh\u00e4ngiger Penetranz fur dieses EEG\u2010Merkmal verantwortlich ist.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1528-1157.1975.tb06059.x","type":"journal-article","created":{"date-parts":[[2007,11,5]],"date-time":"2007-11-05T15:07:38Z","timestamp":1194275258000},"page":"285-293","source":"Crossref","is-referenced-by-count":158,"title":["Benign Epilepsy of Childhood with Centrotemporal EEG Foci: A Genetic Study"],"prefix":"10.1111","volume":"16","author":[{"given":"J.","family":"Heijbel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Blom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rasmuson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1972.tb05164.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1975.tb04730.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1972.tb04396.x"},{"key":"e_1_2_1_5_1","unstructured":"Blom S. Heijbel J. andBergfors PG.The incidence of seizures in children in the County of Vasterbotten(in preparation)."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196410292711803"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1542\/peds.36.2.207","article-title":"Hereditary characteristics of familial temporal\u2010central focal epilepsy","volume":"36","author":"Bray PF","year":"1965","journal-title":"Pediatrics"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1973.tb03942.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a070672"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091791"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(58)90053-1"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1951.03670060005002"},{"key":"e_1_2_1_13_1","first-page":"574","volume-title":"Epilepsy and Related Disorders","author":"Lennox WG.","year":"1960"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1939.02800360016005"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1969.tb03825.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1973.tb03977.x"},{"key":"e_1_2_1_17_1","first-page":"244","article-title":"A propos \u010fune forme singuli\u00e8re \u010f\u00e9pilepsie de \u013eenfant","volume":"116","author":"Loiseau P.","year":"1967","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_18_1","unstructured":"Merlis JK.Genetic factors in the classification of the epilepsies.3rd European Symposium on Epilepsy Manuscripts and Abstracts 1970."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.10.3.228"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.11.6.474"},{"key":"e_1_2_1_21_1","unstructured":"Mortureux Y.Etude electro\u2010clinique de certains paroxysmes \u010fexpression rolandique chez \u013eenfant.These de medecine Bordeaux1966 191pp."},{"key":"e_1_2_1_22_1","first-page":"201","article-title":"Les pointes\u2010ondes pr\u00e9rolandiques: Expression E.E.G. tr\u00e8s partiuli\u00e8re. \u00c9tude \u00e9lectroclinique de 21 cas","volume":"99","author":"Nayrac P.","year":"1958","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_23_1","first-page":"33","article-title":"Genetic and social aspects of the epilepsies of childhood","volume":"47","author":"Ounsted C.","year":"1955","journal-title":"Eug Rev"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1001\/jama.1966.03110160049019","article-title":"Hereditary components in epileptic patients","volume":"198","author":"Rodin E.","year":"1966","journal-title":"JAMA"},{"key":"e_1_2_1_25_1","first-page":"753","volume-title":"Principles of Human Genetics","author":"Stern C.","year":"1960"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1528-1157.1975.tb06059.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1528-1157.1975.tb06059.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T17:26:02Z","timestamp":1698945962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1528-1157.1975.tb06059.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,6]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1975,6]]}},"alternative-id":["10.1111\/j.1528-1157.1975.tb06059.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1528-1157.1975.tb06059.x","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,6]]}}}