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In the past decade, selective calcium channel blockers have been synthesized, aiding in the analysis of calcium charinel subtypes by patch\u2010clamp recordings. It is still a matter of debate whether whether any of the currently available antiepileptic drugs (AEDs) inhibit these conductances as part of their mechanism of action. We tested oxcarbazepine, lamotrigine, and felbamate and found that they consistently inhibited voltage\u2010activated calcium currents in cortical and striatal neurons at clinically relevant concentrations. Low micro\u2010molar concentrations of GP 47779 (the active metabolite of oxcarbazepine) and lamotrigine reduced calcium conductances involved in the regulation of transmitter release. In contrast, felbamate blocked nifedipine\u2010sensitive conductances at concentrations significantly lower than those required to modify <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate (NMDA) responses or sodium currents. Aside from contributing to AED efficacy, this mechanism of action may have profound implications for preventing fast\u2010developing cellular damage related to ischemic and traumatic brain injuries. Moreover, the effects of AEDs on voltage\u2010gated calcium signals may lead to new therapeutic strategies for the treatment of neurodegenerative disorders.<\/jats:p>","DOI":"10.1111\/j.1528-1157.1997.tb01477.x","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T16:16:04Z","timestamp":1123085764000},"page":"959-965","source":"Crossref","is-referenced-by-count":99,"title":["Voltage\u2010Activated Calcium Channels: Targets of Antiepileptic Drug 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