{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:04:21Z","timestamp":1770069861124,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":8212,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A pilot study to assess patient compliance with medication by using a new measurement technique, continuous electronic monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Survey. Compliance monitors were provided to eligible patients at discharge from the hospital to measure drug intake behavior prospectively for a period of 3 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Ambulant patient care after discharge from a geriatric hospital, Krankenhaus Bethanien, which is affiliated with the University Clinic, Heidelberg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>A consecutive convenience sample of 18 independently living elderly patients (median age 76 years) completed the study. The patients were on maintenance therapy with cardiac glycosides and\/or potassium\u2010sparing diuretics prescribed to be taken once daily.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>The monitoring method provides information about patients' real timing of drug use by continuously recording date and time of openings and closings of the medication containers (monitors). In addition to a standard measure, the percentage of prescribed doses taken, information about regularity of drug use is obtained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compliance, percentage of prescribed doses taken, was remarkably variable; it ranged from 24% to 100%, 95% CI: 62%\u201084%. Mean compliance declined from the first to the third week after discharge, 85% vs 69%, 95% CI: 74%\u201095% and 56%\u201081%, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). Omissions of doses, the predominant pattern of non\u2010compliance, were observed in 17 of 18 patients. Regularity of dose timing, as defined by the number of interdose intervals within 24 h \u00b1 15%, varied from 10% to 100%, 95% CI: 46%\u201076%.\n                      <jats:bold>Conclusions<\/jats:bold>\n                      : Continuous electronic monitoring revealed highly variable compliance in patients prescribed maintenance therapy. Even with a once\u2010daily regimen, persistent and high compliance cannot be assumed. The monitoring technique may be of great value to research and, possibly, to practical therapeutic management.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1532-5415.1992.tb01806.x","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T01:37:48Z","timestamp":1430271468000},"page":"1151-1155","source":"Crossref","is-referenced-by-count":42,"title":["Measurement of Drug Compliance by Continuous Electronic Monitoring: A Pilot Study in Elderly Patients Discharged From 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