{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:54:18Z","timestamp":1774436058008,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T00:00:00Z","timestamp":1336521600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine the associations between depressive symptoms, antidepressant use, and duration of use with incident frailty 3\u00a0years later in nonfrail women aged 65 and older.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Secondary analysis of the\n                      <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\n                      omen's\n                      <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                      ealth\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      nitiative\n                      <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>\n                      bservational\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      tudy (\n                      <jats:styled-content style=\"fixed-case\">WHI<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      ), a prospective cohort study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">WHI<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      was conducted in 40\n                      <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      . clinical centers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Women aged 65 to 79, not frail at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Antidepressant use was assessed through medication container inspection at baseline. Four groups were created according to baseline use and\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      urnam depression screen (range 0\u20131, 0.06 cutoff): antidepressant nonusers without depressive symptoms (reference group), antidepressant nonusers with depressive symptoms, antidepressant users without depressive symptoms, and antidepressant users with depressive symptoms. Frailty components included slowness or weakness, exhaustion, low physical activity, and unintended weight loss, ascertained through self\u2010report and physical measurements at baseline and Year\u00a03.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 27,652 women at baseline, 1,350 (4.9%) were antidepressant users and 1,794 (6.5%) were categorized as depressed. At Year 3, 4,125 (14.9%) were frail. All groups had a greater risk of incident frailty than the reference group. Odds ratios (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      s) ranged from 1.73 (95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      )\u00a0=\u00a01.41\u20132.12) in antidepressant users who were not depressed to 3.63 in antidepressant users who were depressed (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a02.37\u20135.55). All durations of use were associated with incident frailty (&lt;1\u00a0year\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u00a0=\u00a01.95, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a01.41\u20132.68; 1\u20133\u00a0years\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u00a0=\u00a01.99, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a01.45\u20132.74; &gt;3\u00a0years\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u00a0=\u00a01.60, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a01.20\u20132.14).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In older adult women, depressive symptoms and antidepressant use were associated with frailty after 3\u00a0years of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1532-5415.2012.03940.x","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T04:59:49Z","timestamp":1336539589000},"page":"854-861","source":"Crossref","is-referenced-by-count":110,"title":["Antidepressant Use, Depressive Symptoms, and Incident Frailty in Women Aged 65 and Older from the\n                    <scp>W<\/scp>\n                    omen's\n                    <scp>H<\/scp>\n                    ealth\n                    <scp>I<\/scp>\n                    nitiative Observational Study"],"prefix":"10.1111","volume":"60","author":[{"given":"Susan L.","family":"Lakey","sequence":"first","affiliation":[{"name":"Group Health Research Institute Seattle Washingtin"}]},{"given":"Andrea Z.","family":"LaCroix","sequence":"additional","affiliation":[{"name":"Women's Health Initiative Clinical Coordinating Center Fred Hutchinson Cancer Research Center Seattle Washingtin"}]},{"given":"Shelly L.","family":"Gray","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Washington Seattle Washingtin"}]},{"given":"Soo","family":"Borson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences School of Medicine University of Washington Seattle Washington;"}]},{"given":"Carla D.","family":"Williams","sequence":"additional","affiliation":[{"name":"Howard University Cancer Center Washington District of Columbia;"}]},{"given":"Darren","family":"Calhoun","sequence":"additional","affiliation":[{"name":"MedStar Research Institute Phoenix Arizona;"}]},{"given":"Joseph S.","family":"Goveas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Medical College of Wisconsin Milwaukee Wisconsin;"}]},{"given":"Jordan W.","family":"Smoller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital Boston Massachusetts;"}]},{"given":"Judith K.","family":"Ockene","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester Massachusetts;"}]},{"given":"Kamal H.","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine John A. 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