{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:30:09Z","timestamp":1772209809809,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>ABSTRACT<\/jats:title>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>BACKGROUND AND PURPOSE<\/jats:title>\n                    <jats:p>Corpus callosum (CC) is frequently involved in multiple sclerosis (MS). We aimed to investigate the relations between CC microstructure integrity as measured by diffusion tensor imaging (DTI) in relapsing\u2010remitting MS patients with low neurological disability in comparison with age\u2010matched healthy subjects and further to identify correlations between DTI\u2010CC parameters and clinical variables of MS disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>CC volume was measured on 3.0T brain MRI by MS Analyze software. DTI metrics acquired along 31 independent directions were obtained and fractional anisotropy (FA), apparent diffusion coefficient (ADC), longitudinal (\u03bb1) and transverse (\u03bb 2, \u03bb 3) diffusivities were measured in MS patients and healthy subjects. Disease activity was assessed by relapse rate and neurolgical disability by the Extended Disability Status Scale (EDSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Thirty relapsing\u2010remitting MS patients and 30 age\u2010 and sex\u2010matched healthy subjects were studied. CC volume and DTI metrics differed significantly between MS patients and healthy subjects. In MS patients, all DTI parameters correlated with neurological disability. ADC, longitudinal and transverse diffusivity correlated with disease duration. ADC and the transverse diffusivity correlated with relapse rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      <jats:bold>CC DTI parameters, especially ADC and transverse diffusivity correlated with disease variables especially with those associated with clinical activity.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1552-6569.2010.00556.x","type":"journal-article","created":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T17:33:16Z","timestamp":1291224796000},"page":"33-37","source":"Crossref","is-referenced-by-count":36,"title":["Diffusion Tensor Imaging of Corpus Callosum Integrity in Multiple Sclerosis: Correlation with Disease 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