{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:04:56Z","timestamp":1757700296823},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>\n                           <jats:bold>ABSTRACT<\/jats:bold>\n                        <\/jats:title>\n          <jats:sec>\n            <jats:title>OBJECTIVE:<\/jats:title>\n            <jats:p>Hepatitis A vaccination is recommended for patients with chronic hepatitis C. Our aim was to analyze the cost-effectiveness of hepatitis A vaccination in these patients. The specific strategies evaluated were: no vaccination, targeted vaccination, and universal vaccination.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Clinical estimates were based on published data. Costs estimates were based on published data and institutional Medicare reimbursement rates. Health-related quality-of-life weights were derived from published data and expert estimates. The target population consisted of patients 45 yr of age with chronic hepatitis C followed every 6 months until death. We adopted a societal perspective.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Compared with no vaccination, targeted vaccination was associated with an incremental cost-effectiveness ratio of $51,000 per quality-adjusted life-year. The incremental cost-effectiveness ratio of universal vaccination compared with targeted vaccination was $3,900,000 per quality-adjusted life-year. The results were particularly sensitive to the incidence of hepatitis A, probability of fulminant hepatic failure, and costs of hepatitis A antibody screening and vaccination.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Targeted vaccination for hepatitis A in patients with chronic hepatitis C may be a cost-effective strategy to decrease the morbidity and mortality associated with hepatitis A superinfection. Universal vaccination is not a cost-effective alternative to targeted vaccination in this target population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1111\/j.1572-0241.2002.05554.x","type":"journal-article","created":{"date-parts":[[2004,3,29]],"date-time":"2004-03-29T09:05:14Z","timestamp":1080551114000},"page":"721-728","source":"Crossref","is-referenced-by-count":35,"title":["The Cost-Effectiveness of Hepatitis A Vaccination in Patients With Chronic Hepatitis C Viral Infection in The United States"],"prefix":"10.14309","volume":"97","author":[{"given":"Miguel R","family":"Arguedas","sequence":"first","affiliation":[]},{"given":"Gustavo R","family":"Heudebert","sequence":"additional","affiliation":[]},{"given":"Michael B","family":"Fallon","sequence":"additional","affiliation":[]},{"given":"Aaron A","family":"Stinnett","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"issue":"12","key":"b1_1173","first-page":"1","volume":"48","author":"Centers for Disease Control and Prevention","year":"1999","journal-title":"MMWR"},{"key":"b2_1174","first-page":"201","volume":"90","author":"Keeffe EB","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"b3_1175","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801293380503"},{"key":"b4_1176","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270336"},{"key":"b5_1177","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(99)00206-3"},{"key":"b6_1178","volume-title":"Drug Topics Red Book","year":"2000"},{"key":"b7_1179","doi-asserted-by":"publisher","DOI":"10.1001\/jama.276.14.1172"},{"key":"b8_1180","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/0272989X8300300403","volume":"3","author":"Beck JR","year":"1983","journal-title":"Med Decis Making"},{"key":"b9_1181","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/0272989X9301300409","volume":"13","author":"Sonnenberg FA","year":"1993","journal-title":"Med Decis Making"},{"key":"b10_1182","first-page":"1","volume":"47","author":"National Center for Health Statistics","year":"1999","journal-title":"Nat Vital Stat Rep"},{"key":"b11_1183","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1017\/S0266462300008461","volume":"5","author":"Torrance GW","year":"1989","journal-title":"Int J Tech Assess Health Care"},{"key":"b12_1184","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/oso\/9780195108248.003.0004","volume-title":"Cost-effectiveness in health and medicine","author":"Gold MR","year":"1996"},{"key":"b13_1185","volume-title":"Methods for the economic evaluation of health care programmes","author":"Drummond MF","year":"1997","edition":"2"},{"key":"b14_1186","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.24.2088"},{"key":"b15_1187","unstructured":"15. 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