{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:50:10Z","timestamp":1770753010741,"version":"3.50.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T00:00:00Z","timestamp":1255910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["APMIS"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:p>Tissue cyclooxygenase\u20102 (COX\u20102) is a rate\u2010limiting enzyme in prostaglandin synthesis and has been shown to have roles in carcinogenesis and tumor progression. Evaluation of COX\u20102 overexpression in malignancies has been performed mostly on tumors of epithelial origin, and little is known about its presence in mesenchymal tumors, especially gastrointestinal stromal tumors (GIST). COX\u20102 has been reported to be widely expressed in GIST and has been suggested as a potential diagnostic marker. We evaluated the overexpression and roles of COX\u20102 in tumorigenesis in GIST with regard to its relation to prognostic parameters and tumor recurrence. We studied the presence of COX\u20102 expression immunohistochemically and its relation to clinicopathologic prognostic variables in 41 cases of GIST. COX\u20102 was overexpressed in 21 (51%) of 41 tumors. The extent of overexpression was greater in tumors that recurred after surgical resection. COX\u20102 overexpression was also higher in tumors with coagulative necrosis, high mitotic index and an infiltrative pattern of growth. The observation of greater COX\u20102 expression levels in GIST with unfavorable histopathologic variables is contrary to previous reports and consistent with the reported roles of COX\u20102 in carcinogenesis of epithelial malignancies.<\/jats:p>","DOI":"10.1111\/j.1600-0463.2009.02537.x","type":"journal-article","created":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T10:56:58Z","timestamp":1255949818000},"page":"825-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cyclooxygenase\u20102 expression and connection with tumor recurrence and histopathologic parameters in gastrointestinal stromal tumors"],"prefix":"10.1111","volume":"117","author":[{"given":"H\u00dcSEYIN 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