{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:51:17Z","timestamp":1770699077118,"version":"3.49.0"},"reference-count":108,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T00:00:00Z","timestamp":1146182400000},"content-version":"vor","delay-in-days":3070,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p><jats:bold>Summary: <\/jats:bold> The development and function of the immune system is precisely regulated to assure the generation of protective immune responses while avoiding autoimmunity. This regulation is accomplished by the engagement of a multitude of cell\u2010surface receptors which transduce signals that activate or regulate cell differentiative and proliferative pathways. In some cases biologic responses reflect the integration of signals generated by co\u2010aggregation of multiple receptors by complex ligands. For example, B\u2010cell responses to antigen receptor aggregation can be modulated by co\u2010aggregation of receptors for immunoglobulin G (Fc\u03b3RIIB1), complement components (CR2). and 4aL2,6\u2010sialoglycoproteins (CD22). Here we review our recent studies of molecular mechanisms underlying co\u2010receptor modulation of B\u2010cell antigen receptor signaling. Our results define interesting circuitry involving interactions among the B\u2010cell antigen receptor, CD 19 and Fc\u03b3RIIB1. CD 19 may function as an important integrator of positive and negative signals that regulate B\u2010cell antigen receptor signal output.<\/jats:p>","DOI":"10.1111\/j.1600-065x.1997.tb01033.x","type":"journal-article","created":{"date-parts":[[2006,4,30]],"date-time":"2006-04-30T00:04:56Z","timestamp":1146355496000},"page":"127-138","source":"Crossref","is-referenced-by-count":31,"title":["Co\u2010receptor and accessory regulation of B\u2010cell antigen receptor signal transduction"],"prefix":"10.1111","volume":"160","author":[{"given":"Anne Matte","family":"Buhl","sequence":"first","affiliation":[]},{"given":"John C.","family":"Cambier","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,4,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5271.70"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4049\/jimmunol.151.2.730","article-title":"Differential 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