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Recent studies have clarified the sources and the regulation ofIL\u201012 production leading to Th1 development against microbes. Expression of IL\u201012R is necessary for maintaining IL\u201012 responsiveness and controlling Thl lineage commitment. Advances in this area have included a broader understanding of the factors involved in the regulation of the IL\u201012R\u03b22 signaling component. Expression of this receptor subunit in humans is critically influenced by IL\u201012 and type I interferons. IL\u201012 signaling results in STAT4 activation and interferon (IFN)\u2010\u03b3 production. Recent evidence suggests that IL\u201012 also modulates a number of genes involved in leukocyte trafficking. Thus, IL\u201012 is not only an important proinflammatory cytokine, which induces production of IFN\u2010\u03b3 and subsequent activation of phago\u2010cytic cells but also plays a major role in regulating the migration and proper positioning of effector cells.<\/jats:p>","DOI":"10.1111\/j.1600-065x.1999.tb01329.x","type":"journal-article","created":{"date-parts":[[2006,4,30]],"date-time":"2006-04-30T05:32:39Z","timestamp":1146375159000},"page":"65-72","source":"Crossref","is-referenced-by-count":115,"title":["Regulation of the IL\u201012\/IL\u201012R axis: a critical step in T\u2010helper cell differentiation and effector 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