{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:35:07Z","timestamp":1761237307435},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T00:00:00Z","timestamp":1146182400000},"content-version":"vor","delay-in-days":2340,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p><jats:bold>Summary: <\/jats:bold> This review examines the field of current HLA class II transgenic mouse models and the individual approaches applied in production of these mice. The majority of these mice have been created with the objective of obtaining a disease model with clinical features mimicking human autoimmune disease. The development process of a different type of HLA class II transgenic mice, which are designed to function as a substitute for a normal human immune system in studies of human autoantigens, is described. Several HLA\u2010DR4 transgenic lines with normally expressed HLA\u2010DR4 molecules have been produced. To obtain adequate positive selection of the HLA\u2010DR4\u2010restricted CD4<jats:sup>+<\/jats:sup> T\u2010cell repertoire in these mice it is essential both to introduce a human CD4 transgene. and to delete the murine major histocompatibility complex (MHC) class II molecules. These HLA\u2010DR4 transgenic mice have been used to determine the immunogenic CD4<jats:sup>+<\/jats:sup> T\u2010cell epitopes of several human autoantigenic proteins.<\/jats:p>","DOI":"10.1111\/j.1600-065x.1999.tb01377.x","type":"journal-article","created":{"date-parts":[[2006,4,30]],"date-time":"2006-04-30T05:58:05Z","timestamp":1146376685000},"page":"335-343","source":"Crossref","is-referenced-by-count":39,"title":["HLA class II transgenic mice: models of the human CD4<sup>+<\/sup> T\u2010cell immune response"],"prefix":"10.1111","volume":"172","author":[{"given":"Grete","family":"S\u00f8nderstrup","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew 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