{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:32:20Z","timestamp":1762673540526},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T00:00:00Z","timestamp":1146182400000},"content-version":"vor","delay-in-days":5140,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:p>One of the osteopetrotic mutations in the rat, incisors\u2010absent (<jats:italic>ia<\/jats:italic>), exhibits generalized skeletal sclerosis and failure or delay of tooth eruption, characteristics of other osteopetrotic mutations. Osteopetrosis in <jats:italic>ia<\/jats:italic> rats is known to be due to a reduction in bone resorption, the result of the inability of <jats:italic>ia<\/jats:italic> osteoclasts to elaborate a ruffled border. During healing of extraction wounds, especially the initial period, osteoclastic resorption of alveolar bone is considered to be a signficant feature, followed by new bone formation. We have studied extraction wound healing in osteopetrotic (<jats:italic>ia<\/jats:italic>) rats histologically in order to determine if their systemic reduction in bone resorption changes the sequence or rate of alveolar bone healing within and outside the socket after tooth extraction, In <jats:italic>ia<\/jats:italic> rats, the healing process was delayed in comparison to that of normal rats. Many osteoclasts were observed on the surface of alveolar bone, but there was little evidence of resorption. Bone formation in the socket following bone resorption was reduced and the newly formed trabeculae were irregular. In contrast, the quantity of resorption\u2010independent (periosteal) new bone formation outside the socket was exaggerated compared to normal animals. These data indicate that the disturbance of new bone formation in the socket is probably related to the reduction in osteoclastic bone resorption.<\/jats:p>","DOI":"10.1111\/j.1600-0714.1992.tb00092.x","type":"journal-article","created":{"date-parts":[[2006,4,29]],"date-time":"2006-04-29T15:25:30Z","timestamp":1146324330000},"page":"150-155","source":"Crossref","is-referenced-by-count":33,"title":["Alveolar bone remodeling after tooth extraction in normal and osteopetrotic (<i>ia<\/i>) rats"],"prefix":"10.1111","volume":"21","author":[{"given":"Tadashi","family":"Iizuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott C.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Sandy C.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"172","article-title":"Osteopetrosis \u2013 multiple pathways for the interception of osteoclast function","volume":"5","author":"Marks SC","year":"1987","journal-title":"Appl Pathol"},{"key":"e_1_2_1_3_2","first-page":"49","volume-title":"Metabolic bone disease\u2010cellular and tissue mechanisms","author":"Marks SC Jr","year":"1988"},{"key":"e_1_2_1_4_2","first-page":"408","volume-title":"The chemistry and biology of mineralized tissues","author":"Marks SC Jr","year":"1985"},{"key":"e_1_2_1_5_2","first-page":"237","volume-title":"Monographs on pathology of laboratory animals","author":"Marks SC","year":"1991"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001780310"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001380204"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0221-8747(84)90068-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02411278"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1976.tb01760.x"},{"key":"e_1_2_1_11_2","first-page":"227","volume-title":"The biochemistry and physiology of bone","author":"Marks SC Jr","year":"1976"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001410305"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000850105"},{"key":"e_1_2_1_14_2","first-page":"139","article-title":"The development of the teeth of the microphthalmic (mi\/mi) mouse","volume":"153","author":"Al\u2010Douri SMJ","year":"1978","journal-title":"J Anal"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091820305"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0221-8747(81)90028-X"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.2330\/joralbiosci1965.26.745"},{"key":"e_1_2_1_18_2","first-page":"681","article-title":"Effect of indomethacin on healing process of the extraction wound","volume":"68","author":"Koike K","year":"1989","journal-title":"J Dent Res"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092020403"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a104973"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0221-8747(79)90028-6"},{"key":"e_1_2_1_22_2","first-page":"13","volume-title":"Bone histomorphometry: techniques and interpretation","author":"Baron R","year":"1983"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"9847","DOI":"10.1016\/S0021-9258(18)92897-8","article-title":"Gene expression during skeletal development in three osteopetrotic rat mutations: evidence for osteoblast abnormalities","volume":"266","author":"Shalhoub V","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554876"},{"key":"e_1_2_1_25_2","first-page":"167","article-title":"Impaired macrophage migration in incisors absent (ia) osteopetrotic rats","volume":"4","author":"Seifert MF","year":"1988","journal-title":"Bone and Miner"},{"key":"e_1_2_1_26_2","first-page":"225","article-title":"An evaluation of the phagocytic cells in the ia (osteopetrotic) rat: Oxidative metabolism in monocytes and macrophages","volume":"31","author":"Schneider GB.","year":"1982","journal-title":"J Reticulo Soc"},{"key":"e_1_2_1_27_2","first-page":"S164A","article-title":"An evaluation of natural killer cells in osteopetrotic rats by flow cytometry","volume":"4","author":"Schneider GB","year":"1989","journal-title":"J Bone Min Res"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0714.1992.tb00092.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0714.1992.tb00092.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T19:32:53Z","timestamp":1698089573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0714.1992.tb00092.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4]]}},"alternative-id":["10.1111\/j.1600-0714.1992.tb00092.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0714.1992.tb00092.x","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4]]}}}