{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:30:33Z","timestamp":1760887833284},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T00:00:00Z","timestamp":1146182400000},"content-version":"vor","delay-in-days":4745,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:p>Oral colonization by <jats:italic>Pseudomonas aeruginosa<\/jats:italic> possibly precedes the pulmonary infection process in cystic fibrosis (CF) patients. As bacterial aggregates may play a role in establishment of pulmonary infections, involvement of IgA and cations in CF patient saliva\u2010mediated aggregation of <jats:italic>P. aeruginosa<\/jats:italic> was investigated. For colonized patients, <jats:italic>P. aeruginosa<\/jats:italic> aggregation correlated with bacterial\u2010specific and total salivary IgA. Cation or IgA depletion reduced <jats:italic>P. aeruginosa<\/jats:italic> aggregation by saliva from all patients. However, if cations were removed before IgA, and saliva was then reconstituted with calcium, only colonized patient saliva showed reduced aggregation. Aggregation by IgA\u2010depleted saliva was augmented by reconstituting with original IgA. CF patient saliva\u2010mediated aggregation of <jats:italic>P. aeruginosa<\/jats:italic> thus is cation\u2010dependent and enhanced by bacterial\u2010specific IgA. Characterizing the interactions among bacterial aggregating factor(s), cations, and antibodies in CF saliva will help clarify the link between <jats:italic>P. aeruginosa<\/jats:italic> oral colonization and pulmonary infections in CF patients.<\/jats:p>","DOI":"10.1111\/j.1600-0714.1993.tb01058.x","type":"journal-article","created":{"date-parts":[[2006,4,29]],"date-time":"2006-04-29T09:26:37Z","timestamp":1146302797000},"page":"207-213","source":"Crossref","is-referenced-by-count":14,"title":["Role of cations and IgA in saliva\u2010mediated aggregation of <i>Pseudomonas aeruginosa<\/i> in cystic fibrosis patients"],"prefix":"10.1111","volume":"22","author":[{"given":"E. A.","family":"Armstrong","sequence":"first","affiliation":[]},{"given":"B.","family":"Ziola","sequence":"additional","affiliation":[]},{"given":"B. 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