{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:29:31Z","timestamp":1775982571531,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T00:00:00Z","timestamp":1189382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J Oral Sciences"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>In the oral cavity a balanced physiological response is essential for <jats:italic>Streptococcus mutans<\/jats:italic> to survive various types of external challenges. In this study we examined the role of the ClpP serine protease in the response of <jats:italic>S.\u2003mutans<\/jats:italic> towards sodium fluoride, sodium chloride, hydrogen peroxide, and chlorhexidine. By constructing a <jats:italic>clpP<\/jats:italic> promoter\u2013green fluorescent protein reporter strain, we showed increased fluorescence intensities under all types of stress, indicating a need for ClpP under all these challenges. We constructed a <jats:italic>clpP<\/jats:italic> knockout mutant, which proved to be more sensitive to all the challenges than the wild\u2010type strain. This knockout strain also displayed a reduced growth rate, hyperaggregation, and increased biofilm formation. Furthermore, an increased resistance to toxic levels of hydrogen peroxide and chlorhexidine after pre\u2010incubation with sublethal levels of the corresponding compounds was found in the wild\u2010type strain but not in the knockout mutant. In conclusion, ClpP is involved in the general stress response of <jats:italic>S.\u2003mutans<\/jats:italic> and assists the bacteria to resist killing through adaptation.<\/jats:p>","DOI":"10.1111\/j.1600-0722.2007.00477.x","type":"journal-article","created":{"date-parts":[[2007,9,16]],"date-time":"2007-09-16T02:28:26Z","timestamp":1189909706000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The adaptive response of <i>Streptococcus mutans<\/i> towards oral care products: involvement of the ClpP serine protease"],"prefix":"10.1111","volume":"115","author":[{"given":"Dong Mei","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob M.","family":"Ten 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