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A consistent body of evidence supports a role for \u03bc and \u03b4, but not K, receptors in opioid reward. Stimulant reward apparently involves both D<jats:sub>1<\/jats:sub>and D<jats:sub>2<\/jats:sub>receptors; the data favour D<jats:sub>2<\/jats:sub>mediation of stimulant drug reinforcement with a permissive or modulatory role for D<jats:sub>1<\/jats:sub>receptors. The reward\u2010relevant opioid and dopamine receptors, as well as the cannabinoid (marijuana) receptor, share the ability to couple G<jats:sub>i<\/jats:sub>proteins that mediate inhibition of adenylate cyclase and stimulation of K<jats:sup>+<\/jats:sup>conductance. These signal transduction mechanisms thus may be generally implicated in the reinforcing properties of diverse drugs of abuse.<\/jats:p>","DOI":"10.1111\/j.1600-0773.1992.tb00435.x","type":"journal-article","created":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T17:46:21Z","timestamp":1238003181000},"page":"87-94","source":"Crossref","is-referenced-by-count":63,"title":["Receptor Subtypes in Opioid and Stimulant Reward"],"prefix":"10.1111","volume":"70","author":[{"given":"David W.","family":"Self","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690919"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(90)90194-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00172115"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00444692"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)90153-W"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(74)90085-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(87)90219-X"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(89)80019-3"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0022-3565(25)20829-1","article-title":"Reinforcing effects of alfentanyl is mediated by mu opioid receptors: apparent pA2 analysis","volume":"251","author":"Bertalmio A. 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