{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T20:35:03Z","timestamp":1744058103419},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T00:00:00Z","timestamp":1368057600000},"content-version":"vor","delay-in-days":11604,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Reproductive Immunology"],"published-print":{"date-parts":[[1981,8]]},"abstract":"<jats:p><jats:bold>ABSTRACT: <\/jats:bold> The analysis of anti\u2010sheep red blood cell (SRBC) antibody production in the congenic resistant (CR) mouse strains A\/J and A.BY, B10 and B10.A showed that the level of IgG antibodies after immunization with SRBC is controlled by a gene(s) localized in the H\u20102 complex. The use of the h2, h4, and i5 H\u20102 recombinant haplotypes allowed us to map this gene into a region proximally defined by subregion I\u2010J and distally by region H\u20102G. The IgG antibody level is simultaneously under the influence of non\u2010H\u20102 genes, of which those of the A\/J strain origin determine the high IgG level and those of the B10 strain origin determine the low IgG level.<\/jats:p><jats:p>Weights of spleens of the A\/J and B10 mice before and after primary and secondary immunization with SRBC were compared. Before immunization, spleens of the A\/J mice were approximately 10% lighter than those of the B10 mice (0.08 g vs 0.09 g). After the first immunization the spleen weights equalized (\u03b8 = 0.12 g). Four days after the second immunization the weight of the spleens of A\/J mice increased by 312% (relative to the nonimmune state) while that of the B10 mice increased by only 74%. These findings indicate that the cell antigen\u2010specific proliferation in spleens of A\/J mice was considerably higher than that in spleens of B10 mice.<\/jats:p>","DOI":"10.1111\/j.1600-0897.1981.tb00030.x","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T13:31:41Z","timestamp":1368106301000},"page":"168-173","source":"Crossref","is-referenced-by-count":13,"title":["Genetic Regulation of Antibody Response to Sheep Red Blood Cells: Linkage to H\u20102 Complex"],"prefix":"10.1111","volume":"1","author":[{"given":"B.","family":"\u0158\u00cdHOV\u00c1","sequence":"first","affiliation":[]},{"given":"I.","family":"\u0158\u00cdHA","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2013,5,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.5.1063"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(73)90246-3"},{"key":"e_1_2_1_4_2","first-page":"1","article-title":"Regulation of antibody response to SRBC. 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