{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:33:50Z","timestamp":1773063230020,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,8,26]],"date-time":"2010-08-26T00:00:00Z","timestamp":1282780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Paediatrica"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperimmunoglobulinemia D syndrome (HIDS) is a rare, autosomal recessively inherited autoinflammatory disease caused by mutations in the mevalonate kinase gene. HIDS usually starts in infancy with recurrent fever episodes lasting 3\u20137\u2003days and recurring every 4\u20136\u2003weeks, with only partial symptom decrease in adulthood. Fever is typically accompanied by abdominal pain, vomiting, diarrhoea and cervical lymphadenopathy, and sometimes by skin and joint symptoms. Blood leukocytes and serum C\u2010reactive protein are elevated during the episode, and in addition, high levels of interleukine\u20101 (IL\u20101), IL\u20106 and tumour necrosis factor (TNF) and respective soluble receptors have been measured. Instead, serum immunoglobulin D (IgD) is usually normal until 3\u2003years of age. Currently, there is no established treatment for HIDS. Thus far, four children have been successfully treated with etanercep, TNF\u2010alpha inhibitor, and three children with anakinra, IL\u20101 receptor antagonist.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>This review summarizes currently available data on the use biological medicines for HIDS in children. A Finnish 1.5\u2010year\u2010old patient with disease onset at 6\u2003months of age, treated successfully with anakinra, is presented.<\/jats:p>","DOI":"10.1111\/j.1651-2227.2010.01974.x","type":"journal-article","created":{"date-parts":[[2010,8,13]],"date-time":"2010-08-13T00:17:43Z","timestamp":1281658663000},"page":"21-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Hyperimmunoglobulinemia D and periodic fever syndrome in children. Review on therapy with biological drugs and case report"],"prefix":"10.1111","volume":"100","author":[{"given":"M","family":"Korppi","sequence":"first","affiliation":[]},{"given":"ME","family":"van Gijn","sequence":"additional","affiliation":[]},{"given":"K","family":"Antila","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2010,8,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010200"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(01)00149-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2007.07.005"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-008-9178-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01359.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318190cfb7"},{"key":"e_1_2_6_8_2","first-page":"1567","article-title":"Geneettinen kuume \u2013 konsultaatio verkossa, mutaatio kirjekuoressa. 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