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During the furosemide infusion sodium and water excretion increased tenfold and the excretion of potassium and iPGE<jats:sub>2<\/jats:sub>two to three times. The excretion of iPGF<jats:sub>2\u03b1<\/jats:sub>(0.06 \u00b1 0.03 \u03bcg\/min\/100 g kidney weight) was not significantly changed during the furosemide infusion but increased markedly after the infusion and reached a maximum (1.0 \u00b1 0.6 \u03bcg\/min\/100 g) 30 to 45 min later, while the small increase in iPGE<jats:sub>2<\/jats:sub>excretion at this time could be attributed to cross\u2010reaction with PGF<jats:sub>2\u03b1<\/jats:sub>The results indicate that PGE<jats:sub>2<\/jats:sub>might possibly be involved directly in the action of furosemide, while PGF<jats:sub>2\u03b1<\/jats:sub>might participate in sodium and water conserving mechanisms in the rabbit kidney, activated by the drug induced diuresis.<\/jats:p>","DOI":"10.1111\/j.1748-1716.1979.tb06352.x","type":"journal-article","created":{"date-parts":[[2008,12,8]],"date-time":"2008-12-08T18:41:41Z","timestamp":1228761701000},"page":"367-373","source":"Crossref","is-referenced-by-count":17,"title":["Different effects of furosemide on urinary excretion of prostaglandin E<sub>2<\/sub>and F<sub>2\u03b1<\/sub>in rabbits"],"prefix":"10.1111","volume":"105","author":[{"given":"ERNST","family":"OLIW","sequence":"first","affiliation":[]},{"given":"ERIK","family":"\u00c4NGG\u00c5RD","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,12,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(76)90058-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(77)90265-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0022-3565(25)30703-2","article-title":"Natriuretic effect of furosemide after inhibition of prostaglandin synthetase.","volume":"199","author":"BAILIE M. 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