{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:24:58Z","timestamp":1760549098413,"version":"3.28.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1986,6,1]],"date-time":"1986-06-01T00:00:00Z","timestamp":517968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,6,1]]},"abstract":"Abstract<\/jats:title>\n The pharmacological properties of SK&F 94120 on the cardiovascular system have been studied in laboratory animal species. The compound was shown to have positive inotropic activity on hearts from guinea-pig, cat, dog and marmoset in-vitro and in cat and dog in-vivo. These responses in-vivo occurred in association with minimal changes in heart rate. Positive inotropic activity was not caused by SK&F 94120 in rat or hamster hearts in-vitro, thereby indicating a species dependence in myocardial response. SK&F 94120 was shown to have vasodilator activity in cats in-vivo. Detailed studies carried out on anaesthetized cats indicated that the compound caused a balanced dilatation of both resistance and capacitance blood vessels. Haemodynamic studies in anaesthetized cats indicated that, as a consequence of the positive inotropic and vasodilator actions, SK&F 94120 causes significant increases in cardiac output and stroke volume. Studies in conscious dogs showed the compound to be active as a positive inotrope after oral administration. The above properties suggest that this compound possesses useful haemodynamic properties for the treatment of congestive heart failure.<\/jats:p>","DOI":"10.1111\/j.2042-7158.1986.tb04609.x","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T05:19:03Z","timestamp":1302671943000},"page":"452-459","source":"Crossref","is-referenced-by-count":21,"title":["Pharmacological studies with SK&F 94120, a novel positive inotropic agent with vasodilator activity"],"prefix":"10.1093","volume":"38","author":[{"given":"R W","family":"Gristwood","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Smith Kline & French Research Limited , The Frythe, Welwyn, Hertfordshire,","place":["UK"]}]},{"given":"R J","family":"Eden","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Smith Kline & French Research Limited , The Frythe, Welwyn, Hertfordshire,","place":["UK"]}]},{"given":"D A A","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Smith Kline & French Research Limited , The Frythe, Welwyn, Hertfordshire,","place":["UK"]}]},{"given":"E M","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Smith Kline & French Research Limited , The Frythe, Welwyn, Hertfordshire,","place":["UK"]}]}],"member":"286","published-online":{"date-parts":[[1986,6,1]]},"reference":[{"key":"2024110807161000000_cit1","first-page":"226P","volume":"85","author":"Cameron","year":"1985","journal-title":"Br. J. Pharmacol."},{"key":"2024110807161000000_cit2","first-page":"631P","volume":"86","author":"England","year":"1985","journal-title":"Ibid."},{"key":"2024110807161000000_cit3","first-page":"323","volume":"52","author":"Fielden","year":"1974","journal-title":"Ibid."},{"key":"2024110807161000000_cit4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0160-5402(78)90048-7","volume":"1","author":"Flynn","year":"1978","journal-title":"J. Pharmacol. Meth."},{"key":"2024110807161000000_cit5","doi-asserted-by":"crossref","first-page":"224P","DOI":"10.1111\/j.1476-5381.1985.tb11093.x","volume":"85","author":"Gristwood","year":"1985","journal-title":"Br. J. Pharmacol."},{"key":"2024110807161000000_cit6","first-page":"392","volume":"55","author":"Johnston","year":"1975","journal-title":"Ibid."},{"key":"2024110807161000000_cit7","first-page":"173","volume":"60","author":"Johnston","year":"1977","journal-title":"Ibid."},{"volume-title":"Ph.D. Thesis","year":"1973","author":"Taylor","key":"2024110807161000000_cit8"},{"key":"2024110807161000000_cit9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00005344-198103000-00012","volume":"3","author":"Taylor","year":"1981","journal-title":"J. Cardiovasc. Pharmacol."}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.2042-7158.1986.tb04609.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/38\/6\/452\/60534515\/j.2042-7158.1986.tb04609.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/38\/6\/452\/60534515\/j.2042-7158.1986.tb04609.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T07:22:17Z","timestamp":1731050537000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/38\/6\/452\/6176318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6,1]]},"references-count":9,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1986,6,1]]},"published-print":{"date-parts":[[1986,6,1]]}},"URL":"https:\/\/doi.org\/10.1111\/j.2042-7158.1986.tb04609.x","relation":{},"ISSN":["2042-7158","0022-3573"],"issn-type":[{"type":"electronic","value":"2042-7158"},{"type":"print","value":"0022-3573"}],"subject":[],"published-other":{"date-parts":[[1986,6]]},"published":{"date-parts":[[1986,6,1]]}}}