{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:25:09Z","timestamp":1767713109728},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T00:00:00Z","timestamp":1375142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection is a major cause of chronic hepatitis and hepatocellular carcinoma. Currently pegylated interferon (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>) combined with ribavirin remains the best therapeutic approach, although patients infected with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype I may benefit from adding protease inhibitors as \u2018triple therapy\u2019. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) are endogenous small noncoding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s that regulate gene expression and have recently been shown to play an important role in human innate immune response and as an antiviral in chimpanzees. We studied the effect of miR\u2010130a on the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> replication. We found that miR\u2010130a significantly inhibits <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> replication in both <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> replicon and J6\u2010\/<jats:styled-content style=\"fixed-case\">JFH<\/jats:styled-content>1\u2010infected cells. Over expression of miR\u2010130a upregulated the expression of type I <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1\/<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> \u2010\u03b2), <jats:styled-content style=\"fixed-case\">ISG<\/jats:styled-content>15, <jats:styled-content style=\"fixed-case\">USP<\/jats:styled-content>18 and MxA, which are involved in innate immune response and decreased expression of miR\u2010122, a well\u2010defined mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> promoting <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> production. In conclusion, miR\u2010130a inhibits <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> replication\/production by restoring host innate immune responses and\/or downregulating pro\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> miR\u2010122. miR\u2010130a might be a potential drug target by modulating host innate immune responses to combat <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection.<\/jats:p>","DOI":"10.1111\/jvh.12131","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T06:15:20Z","timestamp":1375251320000},"page":"121-128","source":"Crossref","is-referenced-by-count":56,"title":["Micro<scp>RNA<\/scp>\u2010130a inhibits <scp>HCV<\/scp> replication by restoring the innate immune response"],"prefix":"10.1111","volume":"21","author":[{"given":"S.","family":"Li","sequence":"first","affiliation":[{"name":"The Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu China"}]},{"given":"X.","family":"Duan","sequence":"additional","affiliation":[{"name":"The Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu China"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"The Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu China"}]},{"given":"B.","family":"Liu","sequence":"additional","affiliation":[{"name":"The Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu China"}]},{"given":"I.","family":"McGilvray","sequence":"additional","affiliation":[{"name":"The Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu China"},{"name":"Toronto General Research Institute University of Toronto Toronto ON Canada"}]},{"given":"L.","family":"Chen","sequence":"additional","affiliation":[{"name":"The Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu China"},{"name":"Toronto General Research Institute University of Toronto Toronto ON Canada"}]}],"member":"311","published-online":{"date-parts":[[2013,7,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.06.010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.04.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.08.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05842-11"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.02.037"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1644"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0769"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.04.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.04.040"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1113329"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.11.036"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-373"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02321.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04193"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010575"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/107999004772719864"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00417-10"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06205"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108784"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.06.003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.166348"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00290-7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610731104"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/v2071382"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06783"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-907X-3-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178178"}],"container-title":["Journal 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