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We have evaluated the outcome of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 production in the context of splenocyte apoptosis during <jats:italic>Plasmodium berghei ANKA (PbA)<\/jats:italic> infection. Blood\u2010stage <jats:italic>PbA<\/jats:italic> infection confirmed blood\u2013brain barrier disruption, disarray of white pulp, increase in percentage of sub\u2010G0\/G1 and splenocyte apoptosis. Flow cytometric analysis reveals up\u2010regulation of Fas\u2010L followed by caspase\u20108 and caspase\u20103 activation and signifies possible involvement of Fas\u2010L\u2010mediated splenocyte apoptosis. We have observed down\u2010regulation of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 and up\u2010regulation of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 in tissue and serum level, respectively, during <jats:italic>PbA<\/jats:italic> infection. Association between the production of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 and the severity of malaria infection in splenocytes was verified with <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 inhibitor that exacerbated the apoptotic process. In contrary, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 inhibitor causes significant delay in apoptotic process, but could not alter the lethality of parasite. Thus, results from this study suggest that the critical balance between <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 might have a key role on Fas\u2010L\u2010mediated splenocyte apoptosis during experimental cerebral malaria.<\/jats:p>","DOI":"10.1111\/pim.12005","type":"journal-article","created":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T12:39:35Z","timestamp":1348663175000},"page":"73-90","source":"Crossref","is-referenced-by-count":14,"title":["Splenocyte apoptosis in <i>Plasmodium berghei ANKA<\/i> infection: possible role of <scp>TNF<\/scp>\u2010\u03b1 and <scp>TGF<\/scp>\u2010\u03b2"],"prefix":"10.1111","volume":"35","author":[{"given":"T.","family":"Keswani","sequence":"first","affiliation":[{"name":"Immunology Lab Department of Zoology University of Calcutta Kolkata 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