{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T06:13:23Z","timestamp":1696486403906},"reference-count":27,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Auton Autocoid Pharmacol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\n<jats:list>\n\n<jats:list-item><jats:p>Objective assessment of the effect of botulinum toxin A (<jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content>) treatment in primary palmar hyperhidrosis (<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) is attempted by different methods.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>We decided to use for this purpose sympathetic skin responses evoked by train of stimuli (<jats:styled-content style=\"fixed-case\">TSSR<\/jats:styled-content>).<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Twenty patients with severe <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> (five female, median age 24, range 18\u201036) were examined regularly over 3\u00a0months after receiving 50 <jats:styled-content style=\"fixed-case\">UI BT<\/jats:styled-content> in each palm. <jats:styled-content style=\"fixed-case\">TSSR<\/jats:styled-content> were recorded from the palms after sensory stimulation by a train of three supramaximal electric pulses 3\u00a0millisecond apart. Results were compared to longitudinally studied <jats:styled-content style=\"fixed-case\">TSSR<\/jats:styled-content> of 20 healthy sex\u2010 and age\u2010matched control subjects.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>All hyperhidrosis patients reported excellent improvement. <jats:styled-content style=\"fixed-case\">TSSR<\/jats:styled-content> amplitudes decreased at week 1 (mean 54% range 48%\u201067%) and over the following months in a clinically significant trend (slope <jats:italic>R<\/jats:italic>=\u2212.82, <jats:italic>P<\/jats:italic>&lt;.0001). <jats:styled-content style=\"fixed-case\">TSSR<\/jats:styled-content> in controls changed insignificantly (\u00b113% from the baseline). The difference between patients and controls was highly significant at any time point (<jats:italic>P<\/jats:italic>&lt;.001).<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This study suggests that <jats:styled-content style=\"fixed-case\">TSSR<\/jats:styled-content> may help in assessment of treatments in <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>. It confirms objectively the efficacy of <jats:styled-content style=\"fixed-case\">BT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/aap.12050","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T09:48:39Z","timestamp":1479894519000},"page":"23-26","source":"Crossref","is-referenced-by-count":3,"title":["Botulinum toxin A for palmar hyperhidrosis: assessment with sympathetic skin responses evoked by train of stimuli"],"prefix":"10.1111","volume":"36","author":[{"given":"J.Y.","family":"Al\u2010Hashel","sequence":"first","affiliation":[{"name":"Ibn Sina Hospital  Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Youssry","sequence":"additional","affiliation":[{"name":"Ibn Sina Hospital  Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.M.","family":"Rashaed","sequence":"additional","affiliation":[{"name":"Ibn Sina Hospital  Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Shamov","sequence":"additional","affiliation":[{"name":"Neurosurgery Military Medical Academy  Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.T.","family":"Rousseff","sequence":"additional","affiliation":[{"name":"Ibn Sina Hospital  Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.029"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200910020-00002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins5040821"},{"key":"e_1_2_6_5_1","first-page":"392","article-title":"Prevalence of hyperhidrosis among medical students","volume":"38","author":"Westphal FL","year":"2011","journal-title":"Rev Col Bras Cir"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.06.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2012.10.020"},{"issue":"1","key":"e_1_2_6_8_1","first-page":"i31","article-title":"Specific complications and mortality of endoscopic thoracic sympathectomy","volume":"13","author":"Cameron AEP","year":"2003","journal-title":"Clin Autonom Res"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1996.tb00093.x"},{"key":"e_1_2_6_10_1","first-page":"908","article-title":"Canadian Hyperhidrosis Advisory Committee. 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