{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:11:53Z","timestamp":1788376313036,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>An increasing number of immediate hypersensitivity reactions (<jats:styled-content style=\"fixed-case\">HSR<\/jats:styled-content>) have been reported after the use of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>atent <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>lue <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PBV<\/jats:styled-content>) for breast cancer surgery. This is the first study to publish prospective data with systematic allergological assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicentre study in 10 <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>rench cancer centres for over 6 months. All patients scheduled for breast surgery with injection of <jats:styled-content style=\"fixed-case\">PBV<\/jats:styled-content> were included in the study. Patients were screened for past medical history, atopy, and known food and drug allergies. When suspected <jats:styled-content style=\"fixed-case\">HSR<\/jats:styled-content> or unexplained reactions occurred after injection of <jats:styled-content style=\"fixed-case\">PBV<\/jats:styled-content>, blood samples were taken, and plasma histamine and serum tryptase concentrations were measured. <jats:styled-content style=\"fixed-case\">HSR<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">PBV<\/jats:styled-content> was suggested if skin tests performed 6 weeks later were positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine suspected <jats:styled-content style=\"fixed-case\">HSR<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">PBV<\/jats:styled-content> were observed in 1742 patients. Skin tests were positive in six patients, giving an incidence of 0.34%. Four grade <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and two grade <jats:styled-content style=\"fixed-case\">III HSR<\/jats:styled-content> were observed, both requiring intensive care unit treatment. Mean onset time of the reaction was 55\u2009\u00b1\u200937\u2009min. Plasma histamine was elevated in four patients, while serum tryptase was normal. We found no risk factors associated with <jats:styled-content style=\"fixed-case\">HSR<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">PBV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An incidence rate of one in 300 <jats:styled-content style=\"fixed-case\">HSR<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">PBV<\/jats:styled-content> was observed for patients exposed to <jats:styled-content style=\"fixed-case\">PBV<\/jats:styled-content> during sentinel lymph node detection. This rate is higher than rates reported after the use of neuromuscular blocking agents, latex or antibiotics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12003","type":"journal-article","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T10:22:40Z","timestamp":1355134960000},"page":"106-111","source":"Crossref","is-referenced-by-count":32,"title":["Hypersensitivity reactions to <scp>P<\/scp>atent <scp>B<\/scp>lue <scp>V<\/scp> in breast cancer surgery: a prospective multicentre study"],"prefix":"10.1111","volume":"57","author":[{"given":"O.","family":"BRENET","sequence":"first","affiliation":[{"name":"Cancer Center of Angers  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"LALOURCEY","sequence":"additional","affiliation":[{"name":"Cancer Center of Montpellier  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"QUEINNEC","sequence":"additional","affiliation":[{"name":"Cancer Center of Paris  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