{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T09:10:20Z","timestamp":1744189820324},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cyclic alveolar recruitment and derecruitment play a role in the pathomechanism of acute lung injury and may lead to arterial partial pressure of oxygen (<jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub><\/jats:styled-content>) oscillations within the respiratory cycle. It remains unknown, however, if these <jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub><\/jats:styled-content> oscillations are transmitted to the microcirculation. The present study investigates if <jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub><\/jats:styled-content> oscillations can be detected in the pig buccal mucosa microcirculation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Respiratory failure was induced by surfactant depletion in seven pigs. <jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub><\/jats:styled-content> oscillations caused by cyclic recruitment and derecruitment were measured in the thoracic aorta by fast fluorescence quenching of oxygen technology. Haemoglobin oxygen saturation, haemoglobin amount and blood flow in the buccal mucosa microcirculation were determined by combined fast white light spectrometry and laser <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler flowmetry additionally to systolic arterial pressure. Measurements were performed during baseline conditions and during cyclic recruitment and derecruitment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Measurements remained stable during baseline. Respiratory\u2010dependent oscillations occurred in the systemic circulation [<jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub><\/jats:styled-content> oscillations 92 (69\u2013172) <jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content>; systolic arterial pressure oscillations 33 (13\u201335) %] and were related to the respiratory rate (5.0\u2009\u00b1\u20090.2\/min) as confirmed by <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ourier analysis. Synchronised oscillations were detected to the pig buccal mucosa microcirculation [haemoglobin oxygen saturation oscillations 3.4 (2.7\u20134.9) %; haemoglobin amount oscillations 8.5 (2.3\u201313.3) %; blood flow oscillations 66 (18\u201387) %]. The delay between <jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub><\/jats:styled-content>\u2010\\ and microcirculatory oxygen oscillations was 7.2\u2009\u00b1\u20092.8\u2009s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study suggests that <jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub><\/jats:styled-content> oscillations caused by cyclic recruitment and derecruitment were transmitted to the buccal mucosa microcirculation. This non\u2010invasive approach of measuring oxygen waves as a surrogate parameter of cyclic recruitment and derecruitment could be used to monitor <jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub><\/jats:styled-content> oscillations at the bedside.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12019","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T11:34:02Z","timestamp":1353497642000},"page":"320-325","source":"Crossref","is-referenced-by-count":11,"title":["<scp>PaO<sub>2<\/sub><\/scp> oscillations caused by cyclic alveolar recruitment can be monitored in pig buccal mucosa microcirculation"],"prefix":"10.1111","volume":"57","author":[{"given":"K. 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K.","family":"HARTMANN","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical Center of the Johannes Gutenberg\u2010University  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"BOEHME","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical Center of the Johannes Gutenberg\u2010University  Mainz Germany"},{"name":"Department of Anaesthesia, General Intensive Care and Pain Management Medical University Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"SZCZYRBA","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical Center of the Johannes Gutenberg\u2010University  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"HEYLEN","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical Center of the Johannes Gutenberg\u2010University  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"LIU","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical Center of the Johannes Gutenberg\u2010University  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"DAVID","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical Center of the Johannes Gutenberg\u2010University  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"WERNER","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical Center of the Johannes Gutenberg\u2010University  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"MARKSTALLER","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical Center of the Johannes Gutenberg\u2010University  Mainz Germany"},{"name":"Department of Anaesthesia, 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