{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:35:12Z","timestamp":1783989312373,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T00:00:00Z","timestamp":1354233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperbaric prilocaine 20\u2009mg\/ml may be preferable for perianal outpatient surgery. The aim of this prospective, single\u2010centre, randomised, single\u2010blinded, controlled clinical trial was to determine the optimal dosage of hyperbaric prilocaine 20\u2009mg\/ml for a spinal anaesthesia (<jats:styled-content style=\"fixed-case\">SPA<\/jats:styled-content>) in patients undergoing perianal outpatient surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty patients (18\u201380 years\/<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merican <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ociety of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nesthesiologists grade <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>) were enrolled in this study. The patients were randomised to receive 10, 20 or 30\u2009mg of prilocaine for <jats:styled-content style=\"fixed-case\">SPA<\/jats:styled-content>. We measured expansion of the sensory and motor block, evaluated times to walk, void and being eligible for discharge, and determined the demand of analgesics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>116\/120 patients were available for analysis. The expansion of the sensory block gained with an increasing dosage: 10\u2009mg: 3(1\u20136) dermatomes; 20\u2009mg: 4(2\u20136) dermatomes; 30\u2009mg: 5(3\u20137) dermatomes (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Dermatomes were counted upwards beginning with S<jats:sub>5<\/jats:sub>. Also, the motor block gained with an increased dosage (Bromage score 1\u20133: 10\u2009mg: <jats:italic>n<\/jats:italic>\u2009=\u20093, 20\u2009mg: <jats:italic>n<\/jats:italic>\u2009=\u20098 and 30\u2009mg: <jats:italic>n<\/jats:italic>\u2009=\u200918, <jats:italic>P<\/jats:italic>\u2009=\u20090.0002). Patients receiving 10\u2009mg were ready for discharge earlier compared with both other groups (10\u2009mg: 199\u2009\u00b1\u200939\u2009min; 20\u2009mg: 219\u2009\u00b1\u200947\u2009min; 30\u2009mg: 229\u2009\u00b1\u200932\u2009min, <jats:italic>P<\/jats:italic>\u2009=\u20090.0039). Pain occurred earlier in the 10\u2009mg group than in the 30\u2009mg group (10\u2009mg: 168\u2009\u00b1\u200936\u2009min; 30\u2009mg: 205\u2009\u00b1\u200933\u2009min, <jats:italic>P<\/jats:italic>\u2009=\u20090.0427). The demand of additional analgesics was comparable in all dosage groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hyperbaric prilocaine 20\u2009mg\/ml can be applied in dosages of 10, 20 and 30\u2009mg for <jats:styled-content style=\"fixed-case\">SPA<\/jats:styled-content> in perianal surgery. Because of sufficient analgesia, missing motor block and shorter recovery times, 10\u2009mg of hyperbaric prilocaine 20\u2009mg\/ml can be recommended for perianal outpatient surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12031","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T13:28:06Z","timestamp":1354282086000},"page":"249-256","source":"Crossref","is-referenced-by-count":29,"title":["Dosage finding for low\u2010dose spinal anaesthesia using hyperbaric prilocaine in patients undergoing perianal outpatient surgery"],"prefix":"10.1111","volume":"57","author":[{"given":"V.","family":"GEBHARDT","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Surgical Intensive Care Medicine University Medical Centre Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"HEROLD","sequence":"additional","affiliation":[{"name":"Centre of Colo\u2010proctology  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"WEISS","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics University Medical Centre Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"SAMAKAS","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Surgical Intensive Care Medicine University Medical Centre Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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