{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:08:01Z","timestamp":1761919681694},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Providing adequate analgesia and appropriate sedation to high\u2010risk parturients during late second stage labour without compromising foetal safety remains a major challenge, especially in situations when neuraxial block is not applicable. Remifentanil emerged as an option for labour analgesia during the last decade but may be suitable for the facilitation of complicated vaginal deliveries as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review of nine labouring women with significant medical and\/or obstetrical risk factors was conducted. According to the assessment of an experienced obstetrician, vaginal delivery could only be achieved with profound analgesia, and neuraxial block was not possible because of contraindications, technical failure, or shortage of time. Mode of delivery, need for neonatal resuscitation, maternal and neonatal vital parameters, drug consumption, and personnel resource expenses were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Remifentanil target\u2010controlled infusion (TCI) facilitated vaginal delivery in eight out of nine women. No serious adverse events were observed, but three newborns needed initial respiratory support for a few minutes. The total cost of remifentanil <jats:styled-content style=\"fixed-case\">TCI<\/jats:styled-content> administration to facilitate vaginal delivery compared with the estimated additional cost of an emergency caesarean section was negligible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case series suggests that remifentanil TCI may be used to facilitate vaginal delivery in high\u2010risk parturients when other forms of analgesia are limited. However, the small number of patients studied does not allow generalisation of the results; neither can safety concerns be dispelled yet.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12096","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T20:22:42Z","timestamp":1363378962000},"page":"802-808","source":"Crossref","is-referenced-by-count":5,"title":["Remifentanil target\u2010controlled infusion during second stage labour in high\u2010risk parturients: a case series"],"prefix":"10.1111","volume":"57","author":[{"given":"G. L.","family":"SCHWARZ","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"VOLMANEN","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Savonlinna Central Hospital  Savonlinna Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"ALBRECHTSEN","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"BJOERNESTAD","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","first-page":"1","article-title":"Saving Mothers\u2019 Lives: reviewing maternal deaths to make motherhood safer: 2006\u201308. The Eighth Report on Confidential Enquiries into Maternal Deaths in the United Kingdom","volume":"118","author":"Centre for Maternal and Child Enquiries (CMACE)","year":"2011","journal-title":"BJOG"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c03e0c"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182289fe9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199806000-00008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32834fc260"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03022956"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255025"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1999.00857.x"},{"key":"e_1_2_7_10_1","first-page":"200","article-title":"Intravenous patient\u2010controlled analgesia with remifentanil for labor and childbirth in a woman with multiple sclerosis","volume":"54","author":"Lopez\u2010Millan JM","year":"2007","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200204000-00027"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03019731"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bja.a013452"},{"key":"e_1_2_7_14_1","first-page":"75","article-title":"Patient\u2010controlled intravenous analgesia using remifentanil in two parturients with twin pregnancies: case report","volume":"61","author":"Gowreesunker P","year":"2010","journal-title":"Acta Anaesthesiol Belg"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199701000-00005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.3.415"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1471"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2007.01.010"},{"key":"e_1_2_7_19_1","first-page":"75","article-title":"Patient\u2010controlled intravenous analgesia as an alternative to epidural analgesia during labor: questioning the use of the short\u2010acting opioid remifentanil. Survey in the French part of Belgium (Wallonia and Brussels)","volume":"60","author":"Lavand'homme P","year":"2009","journal-title":"Acta Anaesthesiol Belg"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-011-1933-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200204000-00026"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.03975.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei219"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000260645.48266.f1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01509.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181acc6fc"},{"key":"e_1_2_7_27_1","first-page":"539","article-title":"Labor analgesia in preeclampsia: remifentanil patient controlled intravenous analgesia versus epidural analgesia","volume":"20","author":"El\u2010Kerdawy H","year":"2010","journal-title":"Middle East J Anesthesiol"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2010.02390.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200112000-00008"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2003.09.001"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2004.01.005"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2011.06997.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(02)70189-0"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.18.3089"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32834dfa98"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-289X(02)00155-3"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aco.0000084479.59960.3f"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199511000-00009"},{"key":"e_1_2_7_39_1","first-page":"503","article-title":"High\u2010risk pregnancy, costs and DRG reimbursement","volume":"122","author":"Mathisen AB","year":"2002","journal-title":"Tidsskr Nor Laegeforen"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2001.00012.x"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12096","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:52:48Z","timestamp":1700625168000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,15]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/aas.12096"],"URL":"https:\/\/doi.org\/10.1111\/aas.12096","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,15]]}}}