{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:03:54Z","timestamp":1771002234687,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Plasma neutrophil gelatinase\u2010associated lipocalin (p<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>) has been introduced as an early and sensitive biomarker of acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>), with an increased risk for renal replacement therapy (<jats:styled-content style=\"fixed-case\">RRT<\/jats:styled-content>) and adverse outcome in selected critically ill patient groups. Acute respiratory failure is the most common organ dysfunction in critically ill patients with an increased risk for <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>. Accordingly, we hypothesized that p<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> would independently predict adverse outcome in a heterogeneous group of critically ill adult patients with acute respiratory failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Setting<\/jats:title><jats:p>Prospective, multi\u2010centre study in 25 Finnish intensive care units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>p<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> was measured from critically ill patients with acute respiratory failure. We evaluated the predictive value of p<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">RRT<\/jats:styled-content>, and hospital and 90\u2010day mortality first separately, second in addition to the Simplified Acute Physiology Score (<jats:styled-content style=\"fixed-case\">SAPS II<\/jats:styled-content>), and third to <jats:styled-content style=\"fixed-case\">RIFLE<\/jats:styled-content> (Risk, Injury, Failure, Loss, End\u2010Stage Renal Disease) <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> classification. Additionally, we assessed the factors associated with p<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> by linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>We included 369 patients. Median (interquartile range) baseline p<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> was 169 (92\u2013370)\u2009ng\/ml. The areas under receiver operating characteristic curves of baseline p<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> were as follows: 0.733 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.656\u20130.810] for <jats:styled-content style=\"fixed-case\">RRT<\/jats:styled-content>, 0.627 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.561\u20130.693) for hospital, and 0.582 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.520\u20130.645) for 90\u2010day mortality. Present infection, baseline creatinine, operative status, and pancreatitis were independently associated with baseline p<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Baseline p<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> gives no additional value into prediction of hospital and 90\u2010day mortality compared with <jats:styled-content style=\"fixed-case\">RIFLE<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SAPS II<\/jats:styled-content>, and has only moderate predictive power regarding <jats:styled-content style=\"fixed-case\">RRT<\/jats:styled-content> in critically ill adult patients with acute respiratory failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12112","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T23:34:52Z","timestamp":1365118492000},"page":"855-862","source":"Crossref","is-referenced-by-count":12,"title":["Plasma neutrophil gelatinase\u2010associated lipocalin and adverse outcome in critically ill patients with ventilatory support"],"prefix":"10.1111","volume":"57","author":[{"given":"R.","family":"LINKO","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"PETTIL\u00c4","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine Helsinki University Hospital  Helsinki Finland"},{"name":"Institute of Clinical Medicine University of Helsinki  Helsinki 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