{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T19:44:15Z","timestamp":1789328655639,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:00:00Z","timestamp":1368662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The use of neuromuscular blocking agents is still controversial in myasthenic patients but rocuronium could be useful after the introduction of sugammadex as a selective antagonist. The aim of the study was to evaluate the use of rocuronium\u2010sugammadex in myasthenic patients undergoing thoracoscopic thymectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After ethical approval, 10 myasthenic patients undergoing videothoracoscopic\u2010assisted thymectomy were enrolled in the study. Neuromuscular block was achieved with 0.3\u2009mg\/kg rocuronium and additional doses were given according to train\u2010of\u2010four (<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>) monitoring or movement of the diaphragm. Sugammadex 2\u2009mg\/kg was given after surgery. Recovery time (time to obtain a <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> value &gt;\u20090.9) was recorded for all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>All patients were extubated in the operating room after administration of sugammadex. Mean rocuronium dose was 48\u2009mg and the average operation time was 62\u2009min. Recovery time after sugammadex administration was 111\u2009s (min 35; max 240).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A rapid recovery of neuromuscular function was found in myasthenic patients receiving rocuronium when sugammadex was used for reversal. This combination could be a rational alternative for myasthenic patients for whom neuromuscular blockade is mandatory during surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12123","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T10:20:33Z","timestamp":1368699633000},"page":"745-748","source":"Crossref","is-referenced-by-count":46,"title":["Rocuronium and sugammadex in patients with myasthenia gravis undergoing thymectomy"],"prefix":"10.1111","volume":"57","author":[{"given":"Z.","family":"SUNGUR ULKE","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Istanbul University Istanbul Medical Faculty  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"YAVRU","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Istanbul University Istanbul Medical Faculty  Istanbul 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