{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:05:26Z","timestamp":1768892726466,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Increased vascular leakage leading to hypovolaemia and tissue oedema is common in severe sepsis. Hypovolaemia together with oedema formation may contribute to hypoxia and result in multiorgan failure and death. To improve treatment during sepsis, a potential therapeutic target may be to reduce the vascular leakage. Substances affecting the endothelial barrier are interesting in this respect, as it is suggested that increase in vascular leakage depends on reorganisation of the endothelial cells and breakdown of the endothelial barrier. The agonist of the bioactive lipid sphingosine\u20101\u2010phosphate, <jats:styled-content style=\"fixed-case\">FTY720<\/jats:styled-content>, has been shown to modulate the integrity of the endothelium and reduce permeability both in vitro and in vivo. The aim of the present study was to determine if <jats:styled-content style=\"fixed-case\">FTY720<\/jats:styled-content> could reduce the loss of plasma volume during experimental sepsis in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sepsis was induced by ligation and incision of the caecum in the rat. Plasma volume was determined before and 4.5\u2009h after induction of sepsis by a dilution technique using <jats:sup>125<\/jats:sup><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2010labelled albumin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FTY720<\/jats:styled-content> in a dose of 0.2\u2009mg\/kg reduced the loss of plasma during sepsis by approximately 30% compared with vehicle, without any adverse effects on haemodynamic and physiological parameters. The increase in hematocrit and haemoglobin concentration was also found to be higher in the vehicle group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FTY720<\/jats:styled-content> in a dose without haemodynamic side effects reduces loss of plasma volume during experimental sepsis most likely because of reduction in permeability and may therefore be beneficial in sepsis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12130","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T10:04:46Z","timestamp":1369044286000},"page":"713-718","source":"Crossref","is-referenced-by-count":22,"title":["Treatment with the sphingosine\u20101\u2010phosphate analogue <scp>FTY<\/scp> 720 reduces loss of plasma volume during experimental sepsis in the rat"],"prefix":"10.1111","volume":"57","author":[{"given":"CORNELIA","family":"LUNDBLAD","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Lund University Hospital, Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELEN","family":"AXELBERG","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Lund University Hospital, Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PER\u2010OLOF","family":"GR\u00c4NDE","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Lund University Hospital, Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1987.tb08257.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1152\/jappl.1987.62.4.1422","article-title":"Sepsis in sheep reduces pulmonary microvascular sieving capacity","volume":"62","author":"Smith L","year":"1987","journal-title":"J Appl Physiol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/975048"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800840707"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(02)00139-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2011.08.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20088"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200309-1258OC"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000191414.94461.7e"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2008.04.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1981.tb06814.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.02.032"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181b66aa6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31818d0e5d"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000233876.87978.AB"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00002-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2011.01.017"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909494"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2009.06.003"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050579"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12130","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:52:42Z","timestamp":1700625162000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,20]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/aas.12130"],"URL":"https:\/\/doi.org\/10.1111\/aas.12130","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,20]]}}}