{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:32:11Z","timestamp":1755034331890},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,8]],"date-time":"2013-09-08T00:00:00Z","timestamp":1378598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Background<\/jats:title>Procollagen\u2010derived propeptides reflect the rate of collagen synthesis and type I<\/jats:styled-content> cross\u2010linked collagen telopeptides (ICTP<\/jats:styled-content>) collagen I<\/jats:styled-content> degradation. We studied the collagen metabolism to find out if changes seen in acute respiratory distress syndrome patients are observed in patients with acute respiratory failure (ARF<\/jats:styled-content>), and whether multiple organ dysfunction (MOD<\/jats:styled-content>) has impact on it.<\/jats:p><\/jats:sec>Methods<\/jats:title>ARF patients with prolonged hospitalisation at least 21 days were included to the study. Blood samples for serum procollagen aminoterminal propeptide I<\/jats:styled-content> (PINP<\/jats:styled-content>) and III<\/jats:styled-content> (PIIINP<\/jats:styled-content>), and ICTP<\/jats:styled-content> measurements were collected at study admission (day 0) and on days 2, 7, and 21.<\/jats:p><\/jats:sec>Results<\/jats:title>The study population comprised 68 patients. Forty\u2010three patients (63%) developed MOD<\/jats:styled-content> during the first week. PIIINP<\/jats:styled-content> levels increased in all patients over time. The increase was slightly more pronounced in patients with MOD<\/jats:styled-content>. During the first week, the synthesis of PIIINP<\/jats:styled-content> increased more than PINP<\/jats:styled-content>, and PINP<\/jats:styled-content> degradation exceeded its production. By day 21, the balance of collagen metabolites returned to baseline.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The collagen metabolism was altered in ARF<\/jats:styled-content> patients. The first week was dominated by degradation of type I<\/jats:styled-content> collagen and production of type III<\/jats:styled-content> collagen, but by day 21, the collagen composition returned to more stable form.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12182","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T04:50:24Z","timestamp":1378702224000},"page":"1193-1200","source":"Crossref","is-referenced-by-count":4,"title":["Serum markers of collagen synthesis and degradation in acute respiratory failure patients"],"prefix":"10.1111","volume":"57","author":[{"given":"M.","family":"OKKONEN","sequence":"first","affiliation":[{"name":"Division of Anaesthesia and Intensive Care Medicine Department of Surgery Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"G\u00c4DDN\u00c4S","sequence":"additional","affiliation":[{"name":"Division of Intensive Care Department of 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