{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:03:29Z","timestamp":1792181009034,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":648,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1111\/aas.12218","type":"journal-article","created":{"date-parts":[[2013,11,23]],"date-time":"2013-11-23T07:28:33Z","timestamp":1385191713000},"page":"61-73","source":"Crossref","is-referenced-by-count":18,"title":["Donepezil provides positive effects to patients treated with gabapentin for neuropathic pain: an exploratory study"],"prefix":"10.1111","volume":"58","author":[{"given":"A.","family":"BASNET","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"BUTLER","sequence":"additional","affiliation":[{"name":"Multidisciplinary Pain Centre; Uppsala University Hospital; Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. H.","family":"HONOR\u00c9","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"BUTLER","sequence":"additional","affiliation":[{"name":"Multidisciplinary Pain Centre; Uppsala University Hospital; Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. E.","family":"GORDH","sequence":"additional","affiliation":[{"name":"Multidisciplinary Pain Centre; Uppsala University Hospital; Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"KRISTENSEN","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S; M\u00e5l\u00f8v Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. J.","family":"BJERRUM","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"10.1111\/aas.12218-BIB0001|aas12218-cit-0001","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/S0885-3924(03)00065-4","article-title":"Unmet needs in the management of neuropathic pain","volume":"25","author":"Harden","year":"2003","journal-title":"J Pain Symptom Manage"},{"key":"10.1111\/aas.12218-BIB0002|aas12218-cit-0002","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.4065\/mcp.2009.0649","article-title":"Recommendations for the pharmacological management of neuropathic pain: an overview and literature update","volume":"85","author":"Dworkin","year":"2010","journal-title":"Mayo Clin Proc"},{"key":"10.1111\/aas.12218-BIB0003|aas12218-cit-0003","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1001\/jama.280.21.1831","article-title":"Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial","volume":"280","author":"Backonja","year":"1998","journal-title":"JAMA"},{"key":"10.1111\/aas.12218-BIB0004|aas12218-cit-0004","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pain.2007.12.011","article-title":"Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study","volume":"138","author":"Gordh","year":"2008","journal-title":"Pain"},{"key":"10.1111\/aas.12218-BIB0005|aas12218-cit-0005","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1001\/jama.280.21.1837","article-title":"Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial","volume":"280","author":"Rowbotham","year":"1998","journal-title":"JAMA"},{"key":"10.1111\/aas.12218-BIB0006|aas12218-cit-0006","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1586\/14737175.5.6.823","article-title":"Combination pharmacotherapy for neuropathic pain: current evidence and future directions","volume":"5","author":"Gilron","year":"2005","journal-title":"Expert Rev Neurother"},{"key":"10.1111\/aas.12218-BIB0007|aas12218-cit-0007","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1468-1331.2006.01511.x","article-title":"EFNS guidelines on pharmacological treatment of neuropathic pain","volume":"13","author":"Attal","year":"2006","journal-title":"Eur J Neurol"},{"key":"10.1111\/aas.12218-BIB0008|aas12218-cit-0008","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pain.2008.11.019","article-title":"Mechanisms of analgesia by gabapentin and pregabalin-calcium channel alpha2-delta [Cavalpha2-delta] ligands","volume":"142","author":"Taylor","year":"2009","journal-title":"Pain"},{"key":"10.1111\/aas.12218-BIB0009|aas12218-cit-0009","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/ALN.0b013e31818dac9c","article-title":"Gabapentin acts within the locus coeruleus to alleviate neuropathic pain","volume":"109","author":"Hayashida","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1111\/aas.12218-BIB0010|aas12218-cit-0010","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1002\/jnr.21786","article-title":"Pain relief by gabapentin and pregabalin via supraspinal mechanisms after peripheral nerve injury","volume":"86","author":"Tanabe","year":"2008","journal-title":"J Neurosci Res"},{"key":"10.1111\/aas.12218-BIB0011|aas12218-cit-0011","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s00702-010-0494-4","article-title":"Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies","volume":"117","author":"Folkesson","year":"2010","journal-title":"J Neural Transm"},{"key":"10.1111\/aas.12218-BIB0012|aas12218-cit-0012","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1097\/01.anes.0000267605.40258.98","article-title":"Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil","volume":"106","author":"Hayashida","year":"2007","journal-title":"Anesthesiology"},{"key":"10.1111\/aas.12218-BIB0013|aas12218-cit-0013","first-page":"75","article-title":"Cholinergic mechanisms in pain and analgesia","volume":"Suppl","author":"Hartvig","year":"1989","journal-title":"Trends Pharmacol Sci"},{"key":"10.1111\/aas.12218-BIB0014|aas12218-cit-0014","first-page":"1140","article-title":"Postoperative analgesia from intrathecal neostigmine in sheep","volume":"80","author":"Bouaziz","year":"1995","journal-title":"Anesth Analg"},{"key":"10.1111\/aas.12218-BIB0015|aas12218-cit-0015","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1213\/00000539-199603000-00034","article-title":"Cerebrospinal fluid norepinephrine and acetylcholine concentrations during acute pain","volume":"82","author":"Eisenach","year":"1996","journal-title":"Anesth Analg"},{"key":"10.1111\/aas.12218-BIB0016|aas12218-cit-0016","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0022-3565(24)36759-X","article-title":"Enhancement of analgesia from systemic opioid in humans by spinal cholinesterase inhibition","volume":"282","author":"Hood","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/aas.12218-BIB0017|aas12218-cit-0017","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1399-6576.1986.tb02414.x","article-title":"A double-blind trial of the analgesic properties of physostigmine in postoperative patients","volume":"30","author":"Petersson","year":"1986","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1111\/aas.12218-BIB0018|aas12218-cit-0018","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/00000542-199902000-00025","article-title":"The antiallodynic effects of intrathecal cholinesterase inhibitors in a rat model of neuropathic pain","volume":"90","author":"Hwang","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1111\/aas.12218-BIB0019|aas12218-cit-0019","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/00000542-199808000-00027","article-title":"Intrathecal neostigmine, but not sympathectomy, relieves mechanical allodynia in a rat model of neuropathic pain","volume":"89","author":"Lavand'homme","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1111\/aas.12218-BIB0020|aas12218-cit-0020","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1213\/00000539-199908000-00033","article-title":"Systemic physostigmine shows antiallodynic effects in neuropathic rats","volume":"89","author":"P\u00f6yhi\u00e4","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1111\/aas.12218-BIB0021|aas12218-cit-0021","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jcrc.2008.08.003","article-title":"Clinical limitations of acetylcholinesterase antagonists","volume":"24","author":"Caldwell","year":"2009","journal-title":"J Crit Care"},{"key":"10.1111\/aas.12218-BIB0022|aas12218-cit-0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2125.2004.01848.x","article-title":"The safety and tolerability of donepezil in patients with Alzheimer's disease","volume":"58","author":"Jackson","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"10.1111\/aas.12218-BIB0023|aas12218-cit-0023","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/ACO.0b013e32833a1d2f","article-title":"Population pharmacokinetics and pharmacodynamics in anesthesia, intensive care and pain medicine","volume":"23","author":"Heeremans","year":"2010","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1111\/aas.12218-BIB0024|aas12218-cit-0024","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1213\/ane.0b013e3181753288","article-title":"Mixed effect modelling in analgesia trials","volume":"107","author":"Shafer","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1111\/aas.12218-BIB0025|aas12218-cit-0025","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1213\/ane.0b013e31816b94c9","article-title":"The effect of wound instillation of a novel purified capsaicin formulation on postherniotomy pain: a double-blind, randomised, placebo-controlled study","volume":"107","author":"Aasvang","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1111\/aas.12218-BIB0026|aas12218-cit-0026","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0304-3959(87)91074-8","article-title":"The short-form McGill Pain Questionnaire","volume":"30","author":"Melzack","year":"1987","journal-title":"Pain"},{"key":"10.1111\/aas.12218-BIB0027|aas12218-cit-0027","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/03009749409103032","article-title":"A Swedish version of the short-form McGill Pain Questionnaire","volume":"23","author":"Burckhardt","year":"1994","journal-title":"Scand J Rheumatol"},{"key":"10.1111\/aas.12218-BIB0028|aas12218-cit-0028","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual frame work and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"key":"10.1111\/aas.12218-BIB0029|aas12218-cit-0029","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0895-4356(98)00102-4","article-title":"The Swedish SF-36 Health Survey III. Evaluation of criterion-based validity: results from normative population","volume":"51","author":"Sullivan","year":"1998","journal-title":"J Clin Epidemiol"},{"key":"10.1111\/aas.12218-BIB0030|aas12218-cit-0030","volume-title":"NONMEM users guides (1989-1992)","author":"Beal","year":"1992"},{"key":"10.1111\/aas.12218-BIB0031|aas12218-cit-0031","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0169-2607(98)00067-4","article-title":"Xpose - an S-PLUS based population pharmacokinetic-pharmacodynamic model building aid for NONMEM","volume":"58","author":"Jonsson","year":"1999","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1111\/aas.12218-BIB0032|aas12218-cit-0032","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.neuroscience.2006.02.013","article-title":"Inhibitory M2 muscarinic receptors are upregulated in both axotomized and intact small diameter dorsal root ganglion cells after peripheral nerve injury","volume":"140","author":"Hayashida","year":"2006","journal-title":"Neuroscience"},{"key":"10.1111\/aas.12218-BIB0033|aas12218-cit-0033","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1136\/bmj.300.6719.230","article-title":"Analysis of serial measurements in medical research","volume":"300","author":"Matthews","year":"1990","journal-title":"BMJ"},{"key":"10.1111\/aas.12218-BIB0034|aas12218-cit-0034","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0149-2918(03)90011-7","article-title":"Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials","volume":"25","author":"Backonja","year":"2003","journal-title":"Clin Ther"},{"key":"10.1111\/aas.12218-BIB0035|aas12218-cit-0035","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1212\/01.wnl.0000275528.01263.6c","article-title":"Clinical trial outcome in neuropathic pain: relationship to study characteristics","volume":"70","author":"Katz","year":"2008","journal-title":"Neurology"},{"key":"10.1111\/aas.12218-BIB0036|aas12218-cit-0036","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1212\/WNL.65.12_suppl_4.S7","article-title":"Placebo responses in clinical trials of depression and its implications for research on chronic neuropathic pain","volume":"65","author":"Dworkin","year":"2005","journal-title":"Neurology"},{"key":"10.1111\/aas.12218-BIB0037|aas12218-cit-0037","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003974.pub3","article-title":"Placebo interventions for all clinical conditions","volume":"1","author":"Hrobjartsson","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1111\/aas.12218-BIB0038|aas12218-cit-0038","first-page":"2493","article-title":"Donepezil anvendt ved neuropatiske smerte [In Danish]","volume":"42","author":"Bjerrum","year":"2013","journal-title":"Ugeskr Laeger"},{"key":"10.1111\/aas.12218-BIB0039|aas12218-cit-0039","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1097\/00000542-199911000-00038","article-title":"Sex differences in cholinergic analgesia I: a supplemental nicotinic mechanism in normal females","volume":"91","author":"Chiari","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1111\/aas.12218-BIB0040|aas12218-cit-0040","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1097\/00000542-199911000-00039","article-title":"Sex differences in cholinergic analgesia II: differing mechanisms in two models of allodynia","volume":"91","author":"Lavand'homme","year":"1999","journal-title":"Anesthesiology"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12218","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/aas.12218\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T22:54:23Z","timestamp":1746053663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12218"}},"subtitle":["Co-administered gabapentin and donepezil"],"short-title":[],"issued":{"date-parts":[[2013,11,22]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"URL":"https:\/\/doi.org\/10.1111\/aas.12218","relation":{},"ISSN":["0001-5172"],"issn-type":[{"value":"0001-5172","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,22]]}}}