{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T05:44:17Z","timestamp":1696571057450},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intraosseous (<jats:styled-content style=\"fixed-case\">IO<\/jats:styled-content>) access is used in emergency situations to allow rapid initiation of treatment. <jats:styled-content style=\"fixed-case\">IO<\/jats:styled-content> access is also sometimes used for blood sampling, although data on accuracy of such sampling in critical illness are limited. There is also a potential risk that bone marrow fragments in <jats:styled-content style=\"fixed-case\">IO<\/jats:styled-content> samples may damage laboratory equipment. It is ethically questionable to perform a simultaneous comparison between <jats:styled-content style=\"fixed-case\">IO<\/jats:styled-content> and arterial\/venous sampling in critically ill humans. We have, thus, studied the analytical performance of <jats:styled-content style=\"fixed-case\">IO<\/jats:styled-content> sampling in a porcine septic shock model using a cartridge\u2010based analyser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight pigs with endotoxin\u2010induced septic shock were sampled hourly for 6\u2009h, and analysed for blood gases, acid base status, haemoglobin, glucose and lactate using point of care instruments. Samples were taken from three <jats:styled-content style=\"fixed-case\">IO<\/jats:styled-content> cannulae (tibia bilaterally, one with infusion, and humerus), one arterial and one venous. An interaction test was used to assess changes in agreement between methods over time. Bland\u2013Altman plots were constructed to study bias between methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were, to a varying extent, differences between <jats:styled-content style=\"fixed-case\">IO<\/jats:styled-content> and arterial\/venous levels for all studied variables, but agreement did not change significantly during the experiment. A general finding was a large dispersion of differences between methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IO<\/jats:styled-content> sample values should be treated with caution in this setting but may add useful information to the clinical picture. The tibia or humerus may be used for sampling. <jats:styled-content style=\"fixed-case\">IO<\/jats:styled-content> infusion decreases agreement, thus sampling during infusion should be avoided.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12274","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T12:35:41Z","timestamp":1392726941000},"page":"337-344","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of intraosseous samples in endotoxemic shock \u2013 an experimental study in the anaesthetised pig"],"prefix":"10.1111","volume":"58","author":[{"given":"G.","family":"STRANDBERG","sequence":"first","affiliation":[{"name":"Section of Anesthesiology &amp; Intensive Care Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"LARSSON","sequence":"additional","affiliation":[{"name":"Section of Clinical Chemistry Department of Medical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"LIPCSEY","sequence":"additional","affiliation":[{"name":"Section of Anesthesiology &amp; Intensive Care Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"BERGLUND","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"ERIKSSON","sequence":"additional","affiliation":[{"name":"Section of Anesthesiology &amp; Intensive Care Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.08.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.08.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0206"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757\u20137241\u201018\u201337"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jramc-153-04-20"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-011-1937-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/2009-0381-OA.1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199909000-00034"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(89)80274-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.04.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.04.018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12274","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:22:53Z","timestamp":1696497773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,18]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/aas.12274"],"URL":"https:\/\/doi.org\/10.1111\/aas.12274","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,18]]}}}