{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:09:49Z","timestamp":1785344989027,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T00:00:00Z","timestamp":1399939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010983","name":"Health Research Fund of Central Denmark Region","doi-asserted-by":"crossref","award":["1-01-72-85-10"],"award-info":[{"award-number":["1-01-72-85-10"]}],"id":[{"id":"10.13039\/501100010983","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Danish Rheumatism Association","award":["R101-A2016"],"award-info":[{"award-number":["R101-A2016"]}]},{"name":"The Family Hede Nielsen Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dexamethasone has analgesic properties when given intravenously before surgery, but the optimal dose has not been determined. We hypothesised that a dose of 40\u2009mg dexamethasone would improve analgesia after outpatient shoulder surgery compared with 8\u2009mg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised, double\u2010blind, placebo\u2010controlled clinical trial was conducted at<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>orsens<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egional<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital,<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>enmark. Patients scheduled for arthroscopic subacromial decompression and\/or acromioclavicular joint resection as an outpatient procedure (<jats:italic>n<\/jats:italic>\u2009=\u2009101) were randomised to receive intravenous dexamethasone 40\u2009mg (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>40), 8\u2009mg (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>8) or placebo (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>0) before surgery. The primary outcome was pain intensity 8\u2009h after surgery rated on a numeric rating scale of 0 to 10. Secondary outcomes were pain intensity, analgesic consumption and side effects during the first 3 days after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 73 patients were available for analysis: (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>40: 25,<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>8: 26,<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>0: 22 patients). Eight hours after surgery, pain intensity were: [median (interquartile range)] group<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>40: 2 (1\u20134), group<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>8: 2.5 (1\u20135), group<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>0: 4 (2\u20137). There was no significant difference in pain intensity between group<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>40 and<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>8 after 8\u2009h (<jats:italic>P<\/jats:italic>\u2009=\u20090.46) or at any other time. When comparing all three groups, a statistically significant dose\u2013response relationship was seen for present, average and worst pain intensity after 8\u2009h and on the following morning. No differences were found in analgesic consumption. No serious side effects were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although our data supported a dose\u2013response relationship, increasing the dexamethasone dose from 8 to 40\u2009mg did not improve analgesia significantly after outpatient shoulder surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12333","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T03:09:17Z","timestamp":1400036957000},"page":"751-758","source":"Crossref","is-referenced-by-count":20,"title":["Dexamethasone for pain after outpatient shoulder surgery: a randomised, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"58","author":[{"given":"K. T.","family":"BJ\u00d8RNHOLDT","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Horsens Regional Hospital Horsens Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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