{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:12:09Z","timestamp":1773317529761,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T00:00:00Z","timestamp":1408924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Allergy to volatile anaesthetics is extremely rare, but capable of damaging the professional career.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This article presents the case of a 60\u2010year\u2010old surgeon who developed a skin rash on the reverse of hands, which progressively worsened and extended to distant fold areas. Blood tests were normal but for eosinophilia and risen total <jats:styled-content style=\"fixed-case\">IgE<\/jats:styled-content>, with normal specific globulins and skin prick tests for common allergens. After 8 years, a malfunction in the anaesthetic gas scavenging system was found, and symptoms remitted within a week following its replacement. Repeated open application test with sevoflurane led to the appearance of the same lesions in the tested areas and in distant body folds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We hypothesize that the most probable mechanism for the reaction in our patient is systemic allergic contact dermatitis, which is caused by repeated systemic exposure to a hapten that reaches the skin through haematogenous transport in a sensitized patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The report aims to warn about the potential aetiological relationship between exposure to inhaled anaesthetics and allergic manifestations with cutaneous symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12385","type":"journal-article","created":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T07:29:14Z","timestamp":1408951754000},"page":"1151-1153","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term allergic dermatitis caused by sevoflurane: a clinical report"],"prefix":"10.1111","volume":"58","author":[{"given":"J.","family":"LLOR\u00c9NS HERRERIAS","sequence":"first","affiliation":[{"name":"Anaesthesia and Critical Care Department Hospital Cl\u00ednico Universitario de Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"DELGADO NAVARRO","sequence":"additional","affiliation":[{"name":"Anaesthesia and Critical Care Department Hospital Cl\u00ednico Universitario de Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. T.","family":"BALLESTER LUJ\u00c1N","sequence":"additional","affiliation":[{"name":"Anaesthesia and Critical Care Department Consorcio Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"IZQUIERDO PALOMARES","sequence":"additional","affiliation":[{"name":"Anaesthesia and Critical Care Department Hospital Cl\u00ednico Universitario de Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199906000-00049"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200115030-00004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03215855"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2346.2000.00620.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2004.01032.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/bean.2003.0271"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2003.03235.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/51.11.1092"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05749.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1988.tb06644.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01215.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01367.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00445.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.91832"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01233.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer180"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12385","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:03:05Z","timestamp":1695492185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,25]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/aas.12385"],"URL":"https:\/\/doi.org\/10.1111\/aas.12385","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,25]]}}}