{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:37:25Z","timestamp":1765355845237},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>The anesthetic management of patients affected by myasthenia gravis is usually challenging in elective surgery and even more so in emergency procedures. The difficulties involved are several\u2010fold, ranging from the choice of an appropriate muscle relaxant (i.e. one that enables safe and rapid airway management) to neuromuscular monitoring and normal muscular recovery. Additionally, optimizing patient conditions \u2013 either pharmacologically or with plasmapheresis \u2013 before intervention is well beyond the realm of possibility. We discuss the anesthetic management of two myasthenic patients undergoing emergency surgery (for sigmoid perforation and upper gastrointestinal bleeding respectively). In both cases, we opted for rapid\u2010sequence induction with high\u2010dose rocuronium to prevent inhalation of gastric contents. We also report on the implication of neuromuscular monitoring. We found that the rocuronium\u2013sugammadex combination was a useful and effective option in the emergency setting.<\/jats:p>","DOI":"10.1111\/aas.12391","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T04:23:38Z","timestamp":1409718218000},"page":"1154-1158","source":"Crossref","is-referenced-by-count":12,"title":["High\u2010dose rocuronium for rapid\u2010sequence induction and reversal with sugammadex in two myasthenic patients"],"prefix":"10.1111","volume":"58","author":[{"given":"P.","family":"CASAROTTI","sequence":"first","affiliation":[{"name":"Department of Translational Medicine Maggiore Hospital School of Medicine  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"MENDOLA","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Maggiore Hospital School of Medicine  Novara 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