{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:58:27Z","timestamp":1762999107269,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"name":"K\u00c3\u00b8bmand Sven & Ina Hansens Fond"},{"name":"The Danish Council for Independent Research"},{"name":"The Laerdal Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiovascular dysfunction after cardiac arrest is a common finding. It is unknown whether altered endothelium\u2010mediated vasoreactivity contributes to this dysfunction. We hypothesised that cardiac arrest and resuscitation results in impaired endothelial function. This was addressed by measurements of inflammatory and endothelial plasma markers and of endothelium\u2010dependent vasodilatation in coronary and mesenteric arteries in rats after cardiac arrest and resuscitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats underwent either asphyxia\u2010induced cardiac arrest for 5\u2009min and subsequent resuscitation (<jats:italic>n<\/jats:italic>\u2009=\u200930) or a sham procedure (control animals, <jats:italic>n<\/jats:italic>\u2009=\u200939). Animals were euthanised after 30\u2009min or 2\u2009h. Blood was analysed for <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">sE<\/jats:styled-content>\u2010selectin, <jats:styled-content style=\"fixed-case\">sP<\/jats:styled-content>\u2010selectin, <jats:styled-content style=\"fixed-case\">sVCAM<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010\u03b1 and <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>. Arterial rings of the left anterior descending coronary artery and mesenteric resistance arteries were mounted in microvascular myographs, and concentration\u2013response curves were constructed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The plasma levels of the endothelial markers, <jats:styled-content style=\"fixed-case\">sP<\/jats:styled-content>\u2010selectin and <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content> increased following cardiac arrest at both 30\u2009min and 2\u2009h. Acetylcholine\u2010induced endothelium\u2010dependent and mainly nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>)\u2010mediated vasodilatation was impaired in the coronary arteries at 30\u2009min, but not 2\u2009h after resuscitation. Endothelium\u2010derived hyperpolarisation (<jats:styled-content style=\"fixed-case\">EDH<\/jats:styled-content>)\u2010type vasodilatation induced by <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>309 and vasodilatation induced by the <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> donor sodium nitroprusside was unaltered. In parallel with systemic hypotension, mesenteric arteries exhibited a larger response to <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>309 2\u2009h after resuscitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present results show marked endothelial alterations after cardiac arrest and resuscitation reflected by increased endothelial plasma markers, impaired <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\u2010mediated coronary vasodilatation in the early post\u2010resuscitation phase and enhanced <jats:styled-content style=\"fixed-case\">EDH<\/jats:styled-content>\u2010type vasodilatation in mesenteric arteries later in the post\u2010resuscitation phase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12482","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T02:13:17Z","timestamp":1425262397000},"page":"654-667","source":"Crossref","is-referenced-by-count":11,"title":["Impaired <scp>NO<\/scp>\u2010mediated vasodilatation in rat coronary arteries after asphyxial cardiac arrest"],"prefix":"10.1111","volume":"59","author":[{"given":"T. T.","family":"TROELSEN","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Aarhus University Hospital NBG  Aarhus Denmark"},{"name":"Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology Aarhus University  Aarhus Denmark"},{"name":"Department of Anaesthesiology Regional Hospital of Randers  Randers Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"GRANFELDT","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Aarhus University Hospital NBG  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"SECHER","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Aarhus University Hospital NBG  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. K.","family":"T\u00d8NNESEN","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Aarhus University Hospital NBG  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"SIMONSEN","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1729"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.190652"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000246012.68479.49"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31818a82e8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02594-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccx.0000126090.06275.fe"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2009.04.029"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2007.12.013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2011.02.018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2014.02.019"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-007-0657-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1139\/y97-185"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000023891.80661.AD"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050907"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200211000-00012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200007000-00030"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9050"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182186d42"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.38.1.41"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31828a45ef"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581329"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.1.19"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00765.2005"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.179242"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2011.585658"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9016632"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0115fje"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1998.0826"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20077"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920111798280956"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12424"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199908000-00023"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.1.205"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051024"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2009.10.020"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705214"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.05.002"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10016-006-9109-9"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp105"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12482","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:52:22Z","timestamp":1695559942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/aas.12482"],"URL":"https:\/\/doi.org\/10.1111\/aas.12482","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"type":"print","value":"0001-5172"},{"type":"electronic","value":"1399-6576"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}