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This topical review gives a synopsis of <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I and discusses the current concepts of our understanding of <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I in adults, the diagnosis, and treatment options based on the limited evidence found in medical literature. <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I is a multifactorial disorder. Possible pathophysiological mechanisms of <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I are classic and neurogenic inflammation, and maladaptive neuroplasticity. At the level of the central nervous system, it has been suggested that an increased input from peripheral nociceptors alters the central processing mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was conducted using, as electronic bibliographic database, Medline from 1980 until 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An early diagnosis and multidisciplinary treatment are necessary to prevent permanent disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pharmacological treatment of <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I is empirical and insufficiently effective. Further research is needed regarding the therapeutic modalities discussed in the guidelines. Physical therapy is widely recommended as a first\u2010line treatment. The efficacy of local anesthetic sympathetic blockade as treatment for <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> I is questionable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12489","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T11:21:37Z","timestamp":1429701697000},"page":"685-697","source":"Crossref","is-referenced-by-count":99,"title":["Complex regional pain syndrome type I: a comprehensive review"],"prefix":"10.1111","volume":"59","author":[{"given":"M.","family":"Bussa","sequence":"first","affiliation":[{"name":"O.U. of Anesthesia, Intensive Care and Pain Therapy of Sant'Antonio Abate Hospital Casa Santa Erice Trapani Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Guttilla","sequence":"additional","affiliation":[{"name":"O.U. of Anesthesia, Intensive Care and Pain Therapy of Sant'Antonio Abate Hospital Casa Santa Erice Trapani 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