{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:19:58Z","timestamp":1761513598643},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperbaric oxygen (<jats:styled-content style=\"fixed-case\">HBO<\/jats:styled-content><jats:sub>2<\/jats:sub>) treatment has in animal experiments demonstrated antinociceptive effects. It was hypothesized that these effects would attenuate secondary hyperalgesia areas (<jats:styled-content style=\"fixed-case\">SHA<\/jats:styled-content>s), an expression of central sensitization, after a first\u2010degree thermal injury in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen healthy volunteers were examined during two sessions using a randomized crossover design. Volunteers were studied during control conditions (ambient pressure, <jats:styled-content style=\"fixed-case\">F<jats:sub>I<\/jats:sub>O<\/jats:styled-content><jats:sub>2<\/jats:sub>\u2009=\u20090.21) and during <jats:styled-content style=\"fixed-case\">HBO<\/jats:styled-content><jats:sub>2<\/jats:sub> (2.4 standard atmosphere, <jats:styled-content style=\"fixed-case\">F<jats:sub>I<\/jats:sub>O<\/jats:styled-content><jats:sub>2<\/jats:sub>\u2009=\u20091.0, 90\u2009min) conditions in a pressure chamber. Quantitative sensory testing, including assessment of <jats:styled-content style=\"fixed-case\">SHA<\/jats:styled-content>s was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant overall attenuation of <jats:styled-content style=\"fixed-case\">SHA<\/jats:styled-content>s was seen during the <jats:styled-content style=\"fixed-case\">HBO<\/jats:styled-content><jats:sub>2<\/jats:sub> sessions compared with the control\u2010sessions (<jats:italic>P<\/jats:italic>\u2009=\u20090.011). In the eight volunteers starting with the <jats:styled-content style=\"fixed-case\">HBO<\/jats:styled-content><jats:sub>2<\/jats:sub> session, no difference in <jats:styled-content style=\"fixed-case\">SHA<\/jats:styled-content>s compared with control was demonstrated. However, in the nine volunteers starting with the control session, a statistical significant attenuation of <jats:styled-content style=\"fixed-case\">SHA<\/jats:styled-content>s was demonstrated in the <jats:styled-content style=\"fixed-case\">HBO<\/jats:styled-content><jats:sub>2<\/jats:sub> session (<jats:italic>P<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results indicate that <jats:styled-content style=\"fixed-case\">HBO<\/jats:styled-content><jats:sub>2<\/jats:sub> therapy in humans attenuates central sensitization induced by a thermal skin injury, compared with control. These new and original findings in humans corroborate animal experimental data. The thermal injury model may give impetus to future human neurophysiological studies exploring the central effects of hyperbaric oxygen treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12492","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T08:42:55Z","timestamp":1425372175000},"page":"749-762","source":"Crossref","is-referenced-by-count":15,"title":["Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans"],"prefix":"10.1111","volume":"59","author":[{"given":"V. M.","family":"RASMUSSEN","sequence":"first","affiliation":[{"name":"Multidisciplinary Pain Center, Neuroscience Center Rigshospitalet Copenhagen University Hospitals  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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