{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:32:15Z","timestamp":1787315535809,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T00:00:00Z","timestamp":1426636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pain after\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      aesarean section is often treated with opioids with a risk of side effects. Wound infiltration with local anaesthetics is effective and has few side effects, but volume vs. dose concentration has not been examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ninety patients scheduled for elective\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      aesarean section included in a randomised, double\u2010blinded, placebo\u2010controlled trial receiving infiltration with 50\u2009ml ropivacaine 0.5% or 125\u2009ml ropivacaine 0.2% or 50\u2009ml 0.9% saline (placebo) during surgery. Surgery was performed under lumbar spinal anaesthesia. Primary endpoint was post\u2010operative pain. Secondary endpoints were rescue analgesic, post\u2010operative nausea and vomiting, time spent in the postanesthesia care unit (PACU) and time to first mobilisation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No difference in pain response between groups, but time until maximum pain score was prolonged in the ropivacaine 0.5% group compared with the placebo group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0493). The administration of ketobemidone at 24\u2009h post\u2010operatively in the ropivacaine 0.5% group was reduced compared with the placebo group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.020), and between the ropivacaine 0.2% group and the ropivacaine 0.5% group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.044). No significant differences between groups were found concerning time spent in the\n                      <jats:styled-content style=\"fixed-case\">PACU<\/jats:styled-content>\n                      , to first mobilisation or in number of women with nausea\/vomiting (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2265\u20090.05). No complications related to ropivacaine were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Systematic infiltration with a high concentration, low volume compared with low concentration, high volume showed no significant effect on post\u2010operative pain intensity. However, a statistically significant, but clinically limited opioid sparing effect was demonstrated compared with placebo in the high concentration, low volume group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.12509","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T07:14:34Z","timestamp":1426662874000},"page":"632-639","source":"Crossref","is-referenced-by-count":19,"title":["Effect of high\u2010volume systematic local infiltration analgesia in\n                    <scp>C<\/scp>\n                    aesarean section: a randomised, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"59","author":[{"given":"K. R.","family":"LARSEN","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Hvidovre University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. B.","family":"KRISTENSEN","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Hvidovre University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"RASMUSSEN","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Hvidovre University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. H.","family":"RASMUSSEN","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Hvidovre University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"WEBER","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Hvidovre University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"KRISTENSEN","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Hiller\u00f8d Hospital  Hilleroed Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"KEHLET","sequence":"additional","affiliation":[{"name":"Section of Surgical Pathophysiology Rigshospitalet Copenhagen University  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2007.00786.x"},{"key":"e_1_2_8_3_1","unstructured":"Tal og analyse: F\u00f8dselsstastikken 2011 Sundhedsstyrelsen 2012; 11. 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