{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:47:19Z","timestamp":1695620839099},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Anesthesiology and Pain Therapy, Bern University Hospital, Bern, Switzerland","award":["no number"],"award-info":[{"award-number":["no number"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Brain dysfunction is common in sepsis. We aimed to assess whether cerebral perfusion, oxygenation, and\/or metabolism are abnormal during early endotoxemia, and how they may relate to potential neurohistological changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective animal study, we included 12 pigs (weight: 42\u2009\u00b1\u20094\u2009kg; mean\u2009\u00b1\u2009<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) that were exposed to <jats:styled-content style=\"fixed-case\"><jats:italic>E<\/jats:italic><\/jats:styled-content><jats:italic>scherichia coli<\/jats:italic> lipopolysaccharide (<jats:styled-content style=\"fixed-case\"><jats:italic>E<\/jats:italic><\/jats:styled-content><jats:italic>.\u2009coli<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\">LPS B<\/jats:styled-content>0111\u2009:\u2009<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>4, 0.4\u2009\u03bcg\/kg\/h) or saline infusion (<jats:italic>n<\/jats:italic>\u2009=\u20096, each) for 10\u2009h. Systemic hemodynamics, cerebral blood flow, intracranial pressure, and brain tissue oxygen tension were continuously measured. At the end of the experiment, formalin\u2010fixed brains were cut in coronal sections and embedded in paraffin. Afterwards, the sections were cut at 5 microns and stained with hematoxylin and eosin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stable systemic hemodynamics in both groups were associated with higher carotid arterial blood flow after 10\u2009h of endotoxemia (9.0\u2009\u00b1\u20092.2\u2009ml\/kg\/min) compared to controls (6.6\u2009\u00b1\u20091.2\u2009ml\/kg\/min; time\u2010group interaction: <jats:italic>P\u2009=\u20090.014).<\/jats:italic> Intracranial pressure, cerebral perfusion pressure, brain oxygen consumption, and brain tissue oxygen tension were similar in both groups. In four of the six endotoxemic animals but in none of the controls, cerebral tissue lesions were found (encephalomalacia with spongy degeneration of white matter, axonal swelling, and ischemic neuronal thalamic necrosis), including significant venous vascular alterations, predominantly in the brainstem, in three of the four animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early endotoxemia seems to be associated with histological signs of brain damage unrelated to systemic or cerebral hemodynamics or oxygenation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12512","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T10:14:55Z","timestamp":1426587295000},"page":"586-597","source":"Crossref","is-referenced-by-count":0,"title":["Neurohistological abnormalities during early porcine endotoxemia"],"prefix":"10.1111","volume":"59","author":[{"given":"B.","family":"B\u00c4NZIGER","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Therapy Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"REGUEIRA","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"VOGT","sequence":"additional","affiliation":[{"name":"Division of Anesthesiology Vetsuisse Faculty University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"BRANDT","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Therapy Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"VANDEVELDE","sequence":"additional","affiliation":[{"name":"Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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