{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:28:42Z","timestamp":1773008922244,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["01EZ0722"],"award-info":[{"award-number":["01EZ0722"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pelvic intraoperative neuromonitoring (<jats:styled-content style=\"fixed-case\">pIONM<\/jats:styled-content>) aims to identify and spare the autonomic nerves and maintain patients\u2019 quality of life. The effect of anaesthetic agents on the <jats:styled-content style=\"fixed-case\">pIONM<\/jats:styled-content> signal is unknown; therefore, the aim of the present study was to compare the influences of inhalation anaesthesia (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) and total intravenous anaesthesia (<jats:styled-content style=\"fixed-case\">TIVA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty rectal cancer patients undergoing open nerve\u2010sparing total mesorectal excision (<jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content>) were assigned to <jats:styled-content style=\"fixed-case\">pIONM<\/jats:styled-content> under either <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TIVA<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a010 per group). <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> was maintained with sevoflurane and <jats:styled-content style=\"fixed-case\">TIVA<\/jats:styled-content> with propofol. During surgery, pelvic autonomic nerves were electrically stimulated under electromyography (<jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content>) of the internal anal sphincter (<jats:styled-content style=\"fixed-case\">IAS<\/jats:styled-content>). These triggered <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> signals were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The absolute <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> amplitude during <jats:styled-content style=\"fixed-case\">pIONM<\/jats:styled-content> increased to 1.20\u00a0\u03bcV (interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>): 0.94\u20131.6) for <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> and 1.49\u00a0\u03bcV (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>: 0.84\u20132.75) for <jats:styled-content style=\"fixed-case\">TIVA<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002). The relative <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> amplitude increase also was significantly lower for <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> (0.59; <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>: 0.30\u20130.81; <jats:styled-content style=\"fixed-case\">TIVA<\/jats:styled-content>: 0.99; <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>: 0.62\u20132.5), (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to compare the influences of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TIVA<\/jats:styled-content> on the autonomic nervous system. While both anaesthetic regimens proved useful for <jats:styled-content style=\"fixed-case\">pIONM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TIVA<\/jats:styled-content> with propofol may provide better signal quality than <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> with sevoflurane.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12535","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T07:17:03Z","timestamp":1429600623000},"page":"1119-1125","source":"Crossref","is-referenced-by-count":10,"title":["Impact of inhalation vs. intravenous anaesthesia on autonomic nerves and internal anal sphincter tone"],"prefix":"10.1111","volume":"59","author":[{"given":"F.","family":"Heid","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology University Medicine of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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