{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:02:33Z","timestamp":1787752953785,"version":"build-2784847793"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant Hyperthermia (<jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content>) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and\/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. <jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content> is inherited in an autosomal\u2010dominant manner and linked to mutations in the large ryanodine 1 gene (<jats:styled-content style=\"fixed-case\">RYR<\/jats:styled-content>1) gene in the majority of cases. Very few <jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content> patients have been found to carry mutations in the <jats:styled-content style=\"fixed-case\">CACNA<\/jats:styled-content>1S gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this review a large litterature search was carried out and the Swedish <jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content> database consisting of 436 probands who have undergone in\u00a0vitro muscle contraction test (<jats:styled-content style=\"fixed-case\">IVCT<\/jats:styled-content>) during 1984\u20132014 was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve different <jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content> causative mutations have been found in Swedish patients so far. These mutations lead to a disturbed calcium balance in striated muscle tissue. A muscle biopsy for the <jats:styled-content style=\"fixed-case\">IVCT<\/jats:styled-content> or finding of an approved causative mutation are required for the diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A Malignant Hyperthermia susceptible (<jats:styled-content style=\"fixed-case\">MHS<\/jats:styled-content>) patient should be anesthetized with trigger\u2010free anesthesia. There are a few reports of <jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content>\u2010like reactions in patients unrelated to anesthesia. The outcome is dependent on early recognizing of the reaction and fast disconnection of the trigger agents and administration of dantrolene.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12541","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T12:02:48Z","timestamp":1431950568000},"page":"951-961","source":"Crossref","is-referenced-by-count":16,"title":["Malignant hyperthermia, a Scandinavian update"],"prefix":"10.1111","volume":"59","author":[{"given":"M.","family":"Broman","sequence":"first","affiliation":[{"name":"Perioperative and Intensive Care Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Islander","sequence":"additional","affiliation":[{"name":"Perioperative and Intensive Care Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. R.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Biocentre Institute for Human Genetics W\u00fcrzburg University W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.1.118"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181a7c8e5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-013-0011-y"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12224"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200101000-00019"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20512"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nrm1155","article-title":"Calcium signaling: dynamics, homeostasis and remodeling","volume":"4","author":"Berridge M","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036035"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.56.070187.002143"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20356"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/515454"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer132"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181cbd815"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2005.06.008"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181b5ae2d"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.03.006"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.01.016"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32832efa8f"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324128111"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.91"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9743-2"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206605"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200301000-00034"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02051.x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2009.09.008"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182937d8b"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000062"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182a8fad0"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c6b9b2"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-014-0126-9"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318190bb08"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2003.00113.x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01293.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq243"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1993.tb07414.x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-003-0461-7"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000184184.40504.F3"},{"key":"e_1_2_12_39_1","unstructured":"BekerS.Vergleich der therapeutischen Effektivit\u00e4t des Dantrolens zu der neuen hydrophilen Dantrolen\u2010Formulierung (Ryanodex) in Maligne Hyperthermie positiven Schweinen. EMHG Meeting in Riga 2007."},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-012-1347-0"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael179"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.2344\/11-000240.1"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12234"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/56.11.1267"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1997.tb04820.x"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199307000-00003"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.23.2918"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23633"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-10-104"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/86.2.283"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes341"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182a8a998"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12508"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22056"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000063"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep061"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12541","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:09:54Z","timestamp":1695539394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,18]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/aas.12541"],"URL":"https:\/\/doi.org\/10.1111\/aas.12541","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,18]]}}}