{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:15:34Z","timestamp":1761844534311,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Centre for Medical Imaging and Physiology"},{"DOI":"10.13039\/501100011077","name":"Sk\u00e5ne University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research, Kristianstad"},{"name":"Swedish Heart Lung Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Currently 80% of donor lungs are not accepted for transplantation, often due to fluid overload. Our aim was to investigate if forced fluid infusion may be replaced by a new pharmacological therapy to stabilize circulation after brain death in an animal model, and to assess therapy effects on lung function and morphology trough blood gas parameters and state\u2010of\u2010the\u2010art High\u2010resolution CT (<jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Brain death was caused by surgical decapitation. To maintain mean aortic pressure &gt;\u00a060\u00a0mmHg, pigs were treated with forced electrolyte solution infusion (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a06) or the pharmacological therapy (<jats:styled-content style=\"fixed-case\">GII<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a011). <jats:styled-content style=\"fixed-case\">GIII<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) were non\u2010decapitated controls. Lung function was investigated with blood gases and lung morphology with <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> pigs became circulatory instable 4\u20136\u00a0h after brain death in spite of forced fluid infusion, five pigs showed moderate to severe pulmonary edema on <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content> and median final PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> was 29\u00a0kPa (Q1; Q3; range 26; 40; 17\u201376). <jats:styled-content style=\"fixed-case\">GII<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GIII<\/jats:styled-content> were circulatory stable (mean aortic pressure &gt;\u00a080\u00a0mmHg) and median final PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> after 24\u00a0h was 72\u00a0kPa (Q1; Q3; range 64; 76; 53\u201391) (<jats:styled-content style=\"fixed-case\">GII<\/jats:styled-content>) and 66\u00a0kPa (55; 78; 43\u201390) (<jats:styled-content style=\"fixed-case\">GIII<\/jats:styled-content>). On <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content>, only two pigs in <jats:styled-content style=\"fixed-case\">GII<\/jats:styled-content> had mild pulmonary edema and none in <jats:styled-content style=\"fixed-case\">GIII<\/jats:styled-content>. More than 50% of <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content> exams revealed unexpected lung disease even in spite of PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> &gt;\u00a040\u00a0kPa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pharmacological therapy but not forced fluid infusion prevented circulatory collapse and extensive <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content> verified pulmonary edema after acute brain death. <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content> was useful to evaluate lung morphology and revealed substantial occult parenchymal changes justifying efforts toward a more intense use of <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content> in the pre\u2010transplant evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12595","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T08:29:28Z","timestamp":1438936168000},"page":"93-102","source":"Crossref","is-referenced-by-count":6,"title":["Circulation stabilizing therapy and pulmonary high\u2010resolution computed tomography in a porcine brain\u2010dead model"],"prefix":"10.1111","volume":"60","author":[{"given":"G.","family":"Bozovic","sequence":"first","affiliation":[{"name":"Department of Medical Imaging and Physiology Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Steen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sj\u00f6berg","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Schaefer\u2010Prokop","sequence":"additional","affiliation":[{"name":"Department of Radiology Radboud University Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Verschakelen","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospitals Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"H\u00f6glund","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Division of Clinical Chemistry and Pharmacology Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Siemund","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Physiology Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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